A systematic identification of resistance determinants to antisense antibiotics suggests adaptation strategies dependent on the delivery peptide
Adam J. Mulkern, Thu-Hien Vu, Linda Popella, Tobias Kerrinnes, Svetlana Ðurica-Mitić, Manuel Halte, Kylee Dresbach-Hill, Anne‐Catrin Uhlemann, Stephan Uphoff, Lars Barquist, Jörg Vogel, Marco Galardini
This study identifies resistance determinants to antisense antibiotics by analyzing mutations in gram-negative pathogens exposed to CPP-PNA conjugates, revealing adaptation strategies and resistance mechanisms.
Nature Communications · Aug 12, 2026Peer-reviewedMicrobiology