Linda Popella

This study identifies resistance determinants to antisense antibiotics by analyzing mutations in gram-negative pathogens exposed to CPP-PNA conjugates, revealing adaptation strategies and resistance mechanisms.

This study uses ASOs to selectively inhibit mRNA translation in Prevotellaceae species, enabling functional analysis and targeted depletion in synthetic communities.

The paper investigates antisense PNA conjugates against Fusobacterium nucleatum and discovers a non-targeting control PNA, FUS79, with bactericidal activity independent of antisense effects.

This paper develops an RNA toehold switch-based reporter assay to measure ASO uptake efficiency in bacteria and identifies effective cell-penetrating peptides for ASO delivery.

This study uses non-genetic mRNA silencing to identify essential genes in phage-host interactions, revealing new proteins critical for phage replication and host response.

The paper introduces MASON, a webserver for designing antisense oligomers targeting bacterial mRNAs, and demonstrates its off-target prediction capabilities using experimental data.