Nuclear acetyl-CoA accumulation drives reversible RBP hyperacetylation and transcriptome-wide splicing shifts in age-equivalent Alzheimer's disease neurons
Larissa Traxler, Oliver Borgogno, Kylie Champion, Joseph R. Herdy, Monika Dzieciątkowska, Julie A. Reisz, Ayk Petrosyan, Cat Siler, Colin C. Anderson, Elisa Gorostieta-Salas, Raffaella Lucciola, Douglas Galasko, Fred H. Gage, Angelo D' Alessandro, Jérôme Mertens
This study shows that nuclear acetyl-CoA accumulation in Alzheimer's disease neurons causes RBP hyperacetylation and splicing shifts, which can be reversed by inhibiting ACLY.
bioRxiv · Oct 1, 2026 · PreprintNeuroscience