Author

Larissa Traxler

Salk Institute for Biological StudiesORCID 0000-0003-0974-3575Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:long-read sequencing· 1

Frequent Co-Authors

Jérôme MertensiD· 4 shared Fred H. GageiD· 3 shared Joseph R. HerdyiD· 3 shared Austin KangiD· 2 shared Lukas KarbacheriD· 2 shared Oliver Borgogno· 2 shared Raffaella Lucciola· 2 shared Angelo D' Alessandro· 1 shared

Activity by Year

2026-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersNeuroscience

Jérôme MertensORCID

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4 papers

Recent·Most cited

NeurosciencebioRxivPreprintOct 1, 2026

Nuclear acetyl-CoA accumulation drives reversible RBP hyperacetylation and transcriptome-wide splicing shifts in age-equivalent Alzheimer's disease neurons

Larissa Traxler, Oliver Borgogno, Kylie Champion…·Jérôme Mertens

This study shows that nuclear acetyl-CoA accumulation in Alzheimer's disease neurons causes RBP hyperacetylation and splicing shifts, which can be reversed by inhibiting ACLY.

DOI 10.64898/2026.09.26.754222

humanscRNA-seq

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NeurosciencebioRxivPreprintJul 28, 2026

Cytoplasmic DNA Sensing Links LINE-1 Expression to Neuronal Senescence in Alzheimer's Disease

Joseph R. Herdy, Emma E Taylor, Lukas Karbacher…·Fred H. Gage

This study identifies LINE-1 retrotransposons as drivers of neuronal senescence in Alzheimer's disease through cytoplasmic DNA sensing and the cGAS-STING pathway.

DOI 10.64898/2026.07.27.740588

humanbulk RNA-seq

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Cell BiologybioRxivPreprintMay 21, 2026

Autophagy flux during human aging is sex- and cell type-specific, and is associated with physical fitness

Tatiana M. Moreno, Stephanie Heimler, Ryan J. Moran…·Caroline Kumsta

This study examines autophagy flux changes with age in human cell types, finding sex- and cell-type-specific patterns and a link to physical fitness.

DOI 10.64898/2026.05.15.725565

humanbulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintApr 14, 2026

RUNX1 and YY1 modulate neuronal fate and energy metabolism in Alzheimer's disease

Raffaella Lucciola, Joseph R. Herdy, Yatavee Vajaphattana…·Fred H. Gage

This study identifies RUNX1 and YY1 as master transcription factors modulating neuronal fate and energy metabolism in Alzheimer's disease using patient-derived induced neurons and post-mortem brain data.

DOI 10.64898/2026.04.13.716801

humanbulk RNA-seq

𝕏 PostBluesky