Author

Oliver Borgogno

Salk Institute for Biological Studies

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:long-read sequencing· 1

Frequent Co-Authors

Fred H. GageiD· 2 shared Jérôme MertensiD· 2 shared Joseph R. HerdyiD· 2 shared Larissa TraxleriD· 2 shared Angelo D' Alessandro· 1 shared Austin KangiD· 1 shared Ayk Petrosyan· 1 shared C. Frank BennettiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersNeuroscience

Fred H. GageORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Nuclear acetyl-CoA accumulation drives reversible RBP hyperacetylation and transcriptome-wide splicing shifts in age-equivalent Alzheimer's disease neurons

Larissa Traxler, Oliver Borgogno, Kylie Champion, Joseph R. Herdy, Monika Dzieciątkowska, Julie A. Reisz, Ayk Petrosyan, Cat Siler, Colin C. Anderson, Elisa Gorostieta-Salas, Raffaella Lucciola, Douglas Galasko, Fred H. Gage, Angelo D' Alessandro, Jérôme Mertens

This study shows that nuclear acetyl-CoA accumulation in Alzheimer's disease neurons causes RBP hyperacetylation and splicing shifts, which can be reversed by inhibiting ACLY.

bioRxiv · Oct 1, 2026 · PreprintNeuroscience

Cytoplasmic DNA Sensing Links LINE-1 Expression to Neuronal Senescence in Alzheimer's Disease

Joseph R. Herdy, Emma E Taylor, Lukas Karbacher, Oliver Borgogno, Larissa Traxler, Jessica Lagerwall, Vincent A. Huynh, Zornitsa V Lefterova, Austin Kang, Carlota Tosat‐Bitrián, Maxfield M. G. Kelsey, John M. Sedivy, Subhash C. Sinha, Li Gan, C. Frank Bennett, , Fred H. Gage

This study identifies LINE-1 retrotransposons as drivers of neuronal senescence in Alzheimer's disease through cytoplasmic DNA sensing and the cGAS-STING pathway.

bioRxiv · Jul 28, 2026 · PreprintNeuroscience