Author

Raffaella Lucciola

Salk Institute for Biological Studies

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Neuroscience· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:metabolomics· 2 Assay:proteomics· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

Fred H. GageiD· 3 shared Jérôme MertensiD· 3 shared Joseph R. HerdyiD· 3 shared Jeffrey R. JonesiD· 2 shared Larissa TraxleriD· 2 shared Michael S. CuocoiD· 2 shared Thaís S. SabedotiD· 2 shared Angelo D' Alessandro· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersNeuroscience

Fred H. GageORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

An age-preserving neuronal iSpheroid platform for modeling human aging and Alzheimer disease

Samhan Alsolami, Meiyan Wang, Thaís S. Sabedot, Upendra Singh, Brian Kirk, Lisa E. Mitchell, Melissa Hernandez, Nicholas J. Skvir, Chynna Bowman, Kotaro Oiwa, Ravi Agarwal, Marjan Mahmoudi, Michael S. Cuoco, Elise MacDonald, Samuel Cranston, , Fred H. Gage

This paper introduces an age-preserving neuronal iSpheroid platform that models human aging and Alzheimer's disease, revealing disease-associated metabolic changes and potential therapeutic targets.

bioRxiv · Oct 1, 2026 · PreprintNeuroscience

Nuclear acetyl-CoA accumulation drives reversible RBP hyperacetylation and transcriptome-wide splicing shifts in age-equivalent Alzheimer's disease neurons

Larissa Traxler, Oliver Borgogno, Kylie Champion, Joseph R. Herdy, Monika Dzieciątkowska, Julie A. Reisz, Ayk Petrosyan, Cat Siler, Colin C. Anderson, Elisa Gorostieta-Salas, Raffaella Lucciola, Douglas Galasko, Fred H. Gage, Angelo D' Alessandro, Jérôme Mertens

This study shows that nuclear acetyl-CoA accumulation in Alzheimer's disease neurons causes RBP hyperacetylation and splicing shifts, which can be reversed by inhibiting ACLY.

bioRxiv · Oct 1, 2026 · PreprintNeuroscience

RUNX1 and YY1 modulate neuronal fate and energy metabolism in Alzheimer's disease

Raffaella Lucciola, Joseph R. Herdy, Yatavee Vajaphattana, Lukas Karbacher, Thaís S. Sabedot, Michael S. Cuoco, Larissa Traxler, Austin Kang, Mack B. Reynolds, Jeffrey R. Jones, Simon T. Schafer, Jérôme Mertens, Fred H. Gage

This study identifies RUNX1 and YY1 as master transcription factors modulating neuronal fate and energy metabolism in Alzheimer's disease using patient-derived induced neurons and post-mortem brain data.

bioRxiv · Apr 14, 2026 · PreprintNeuroscience