Acute rapamycin treatment reveals novel mechanisms of behavioral, physiological, and functional dysfunction in a maternal inflammation mouse model of autism and sensory over-responsivity
Janel E. Le Belle, Michael C. Condro, Carlos Cepeda, Katerina D. Oikonomou, Kaleab K. Tessema, L Dudley, J Schoenfield, Riki Kawaguchi, Daniel H. Geschwind, Alcino J. Silva, Ziyang Zhang, Kevan M. Shokat, Neil G. Harris, HI Kornblum
The paper investigates acute rapamycin treatment in a maternal inflammation mouse model of autism, showing rapid rescue of behavioral and functional dysfunctions linked to mTOR pathway activation.
bioRxiv · Jul 8, 2024 · PreprintNeuroscience