Author

L. A. Basso

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

C. V. Bizarro· 4 shared P. Machado· 4 shared B. L. Abbadi· 3 shared A. P. D. d. Souza· 2 shared G. Cassao· 2 shared K. H. Antunes· 2 shared M. A. Perello· 2 shared A. d. M. Czeczot· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersMicrobiology

C. V. Bizarro

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Identification and characterization of new structural scaffolds modulating the activity of Mycobacterium tuberculosis dihydroneopterin aldolase (FolB) in vitro

V. C. d. A. Falcao, A. d. M. Czeczot, M. M. Alam, K.-H. P. Park, J. Heo, M. Woo, A. M. Camini, L. F. S. M. Timmers, D. Shum, M. A. Perello, L. A. Basso, P. Machado, C. V. Bizarro, V. P. Delorme

The paper identifies and characterizes new structural scaffolds that modulate the activity of Mycobacterium tuberculosis dihydroneopterin aldolase (FolB) in vitro, finding compounds with IC50 values ranging from 2.6 to 47 μM.

bioRxiv · Nov 21, 2023 · PreprintBiochemistry

SARS-CoV-2 immune complex triggers human monocyte necroptosis

L. Santos, K. H. Antunes, G. Cassao, J. I. Goncalves, B. L. Abbadi, C. V. Bizarro, L. A. Basso, P. Machado, A. P. D. d. Souza, B. Porto

This study shows SARS-CoV-2 and its immune complexes induce monocyte necroptosis via RIPK3 and MLKL, with Syk kinase involvement, and links elevated LDH to COVID-19 pathogenesis.

bioRxiv · Oct 13, 2022Immunology

OM-85 reduces SARS-COV-2 viral RNA expression in nasopharyngeal cells from COVID-19 patients

G. Cassao, K. H. Antunes, J. I. B. Goncalves, L. D. Santos, B. L. Abbadi, C. V. Bizarro, P. Machado, L. A. Basso, C. Pasquali, R. Stein, A. P. D. d. Souza

The paper shows OM-85 reduces SARS-CoV-2 N1 gene expression and increases RIG-I gene expression in nasopharyngeal cells from COVID-19 patients.

bioRxiv · Jul 29, 2022 · PreprintMicrobiology

Evaluating aroA gene essentiality and EPSP synthase vulnerability in Mycobacterium smegmatis under different nutritional conditions

M. A. Duque-Villegas, B. L. Abbadi, P. R. Romero, L. Galina, P. F. Dalberto, V. S. Rodrigues-Junior, C. D. Roth, R. S. Rambo, E. V. de Souza, M. A. Perello, P. Machado, L. A. Basso, C. V. Bizarro

This study evaluates the essentiality of the aroA gene and vulnerability of its enzyme EPSPS in Mycobacterium smegmatis under different nutritional conditions using gene knockout, knockdown, and kinetic assays.

bioRxiv · Mar 2, 2020 · PreprintMicrobiology