bioRxivMicrobiologyPreprint
OM-85 reduces SARS-COV-2 viral RNA expression in nasopharyngeal cells from COVID-19 patients
G. Cassao, K. H. Antunes, J. I. B. Goncalves, L. D. Santos, B. L. Abbadi, C. V. Bizarro, P. Machado, L. A. Basso, C. Pasquali, R. Stein, A. P. D. d. Souza
Abstract
OM-85 is a bacterial lysate from common respiratory tract pathogens, with an excellent safety profile, widely used to prevent recurrent respiratory tract infections. Several studies have been reporting the antiviral roles of OM-85. Here we demonstrated the effect of ex-vivo OM-85 exposure in nasopharyngeal cells collected from COVID-19 patients. OM-85 decreased the SARS-CoV-2 N1 gene expression and increased RIG-I (DDX58) gene expression in these cells. These data support the antiviral effect of OM-85 against SARS-CoV-2.
- organism: human
- assay: bulk RNA-seq
- research focus: host-pathogen & immune response
- approach: experimental assay
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