Author

L. A. Miles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

R. L. Bowman· 3 shared A. D. Goldberg· 2 shared I. S. Csete· 2 shared M. P. Carroll· 2 shared R. L. Levine· 2 shared S. E. Meyer· 2 shared S. F. Cai· 2 shared W. Xiao· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersCancer Biology

R. L. Bowman

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Author profile →

3 papers

Recent·Most cited

Single cell genotypic and phenotypic analysis of measurable residual disease in acute myeloid leukemia

T. T. Robinson, R. L. Bowman, S. Persaud, Y. Liu, Q. Gao, J. Zhang, X. Sun, L. A. Miles, S. F. Cai, A. Sciambi, A. Llanso, F. A. Christopher, A. D. Goldberg, A. Dogan, M. Roshal, , W. Xiao

The paper develops a single-cell MRD assay that detects residual leukemic clones with high sensitivity and reveals clonal architecture in AML.

bioRxiv · Sep 20, 2022 · PreprintPathology

Modeling clonal evolution and oncogenic dependency in vivo in the context of hematopoietic transformation

R. L. Bowman, A. Dunbar, T. Mishra, W. Xiao, M. R. Waarts, I. Fernandez Maestre, S. E. Eisman, L. Cai, S. F. Cai, P. Sanchez Vela, S. Mowla, A. R. Martinez Benitez, Y. Park, I. S. Csete, A. Krishnan, , R. L. Levine

This study models clonal evolution and oncogenic dependency in hematopoietic transformation using reversible mutagenesis and allelic frameworks.

bioRxiv · May 18, 2022 · PreprintCancer Biology

Single cell mutational profiling delineates clonal trajectories in myeloid malignancies

L. A. Miles, R. L. Bowman, T. R. Merlinsky, I. S. Csete, A. Ooi, R. Durruthy-Durruthy, M. Bowman, C. Famulare, M. A. Patel, P. Mendez, C. Ainali, M. Manivannan, S. Sahu, A. D. Goldberg, K. Bolton, , R. L. Levine

This study uses single-cell mutational profiling to analyze clonal trajectories in myeloid malignancies, revealing patterns of mutation acquisition and clonal complexity.

bioRxiv · Feb 7, 2020 · PreprintCancer Biology