S. Sahu

Peptide-enabled ribonucleoprotein delivery for CRISPR engineering (PERC) in primary human immune cells and hematopoietic stem cells

This paper introduces PERC, a method for efficient CRISPR editing in primary human immune cells and HSPCs using a peptide reagent, achieving over 90% editing efficiency without specialized equipment.

Broad de-regulated U2AF1 splicing is prognostic and augments leukemic transformation via protein arginine methyltransferase activation

The paper identifies a splicing mechanism in AML independent of mutations, showing it drives poor prognosis and can be targeted with PRMT5 inhibition.

Protein condensate fusion mapping using Hippopede curve

The paper uses hippopede curves to quantify biophysical properties of protein condensates during fusion.

Identifying Selectivity Filters in Protein Biosensor for Ligand Screening

The paper identifies selectivity filters in MopR, a bacterial phenol biosensor, that screen ligands based on chemical features and size, revealing conserved mechanisms for ligand selection.

Deferoxamine as adjunct therapeutics for tuberculosis

This study shows Deferoxamine (DFO) has antimycobacterial properties and can reduce Mtb burden when used as an adjunct to standard tuberculosis treatments.

In vivo metabolomics identifies CD38 as an emergent vulnerability in LKB1-mutant lung cancer

The paper identifies CD38 as a therapeutic target in LKB1-mutant lung cancer through in vivo metabolomics and shows that targeting CD38 inhibits tumor growth.

Salmonella Typhimurium effector SseI regulates host peroxisomal dynamics to acquire lysosomal cholesterol for better intracellular growth

The paper shows Salmonella effector SseI recruits peroxisomes to SCVs, activates ARF-1, and facilitates cholesterol transport for bacterial growth.

Spatially controlled microtubule nucleation and organization from crosslinker MAP65 condensates

This study shows that MAP65-1 forms phase-separated condensates that nucleate microtubule bundles in plant cells, suggesting a universal mechanism for microtubule organization.

Berberine as siderophore from Talaromyces trachyspermus: augmentation and characterization".

The paper optimizes and characterizes berberine production by Talaromyces trachyspermus, identifying it as a catecholate siderophore with clinical relevance.

Troxerutin acts on complement mediated inflammation to ameliorate arthritic symptoms in rats.

This study shows that troxerutin reduces arthritis symptoms in rats by modulating complement-mediated inflammation.

Single cell mutational profiling delineates clonal trajectories in myeloid malignancies

This study uses single-cell mutational profiling to analyze clonal trajectories in myeloid malignancies, revealing patterns of mutation acquisition and clonal complexity.

Self-Organization of Spindle-Like Microtubule Structures

This study investigates microtubule self-organization using crosslinkers alone, revealing that antiparallel crosslinker concentration can form spindle-like structures without motor activity.

Analyses of the core eukaryotic protein subunit of telomerase support extensive adaptation to different evolutionary and life histories in the Metazoa

This study analyzes TERT sequence and regulatory evolution across Metazoa, revealing extensive adaptation to diverse life histories and evolutionary pressures.