S. E. Eisman

cellPLATO: an unsupervised method for identifying cell behaviour in heterogeneous cell trajectory data

cellPLATO identifies cell behaviour in trajectory data by clustering morphology and motility metrics, revealing IL-15's role in increasing NK cell migration plasticity.

Mapping human natural killer cell development in pediatric tonsil by imaging mass cytometry & high-resolution microscopy

This study maps human natural killer cell development in pediatric tonsil using imaging mass cytometry and high-resolution microscopy, revealing stage-specific localization and interactions.

Modeling clonal evolution and oncogenic dependency in vivo in the context of hematopoietic transformation

This study models clonal evolution and oncogenic dependency in hematopoietic transformation using reversible mutagenesis and allelic frameworks.

Jak2V617F Reversible Activation Shows an Essential Requirement for Jak2V617F in Myeloproliferative Neoplasms

This study shows that reversible activation of Jak2V617F in a mouse model demonstrates its essential role in myeloproliferative neoplasms and highlights the therapeutic potential of mutant-specific JAK2 inhibition.

Fibroblast activation protein regulates natural killer cell migration, extravasation and tumor infiltration

This study shows that fibroblast activation protein (FAP) is expressed by human NK cells and promotes their migration, extravasation, and tumor infiltration, suggesting FAP as a target to enhance NK cell-based therapies.