R. L. Levine

Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer

This study shows that hematopoietic Dnmt3a haploinsufficiency worsens colitis-associated colon cancer by promoting angiogenesis, which can be targeted with axitinib.

Modeling clonal evolution and oncogenic dependency in vivo in the context of hematopoietic transformation

This study models clonal evolution and oncogenic dependency in hematopoietic transformation using reversible mutagenesis and allelic frameworks.

Jak2V617F Reversible Activation Shows an Essential Requirement for Jak2V617F in Myeloproliferative Neoplasms

This study shows that reversible activation of Jak2V617F in a mouse model demonstrates its essential role in myeloproliferative neoplasms and highlights the therapeutic potential of mutant-specific JAK2 inhibition.

Integrated Single-Cell Genotyping and Chromatin Accessibility Charts JAK2V617F Human Hematopoietic Differentiation

This paper develops GoT-ChA to link genotypes to chromatin accessibility in single cells, revealing JAK2V617F mutation-induced epigenetic changes in hematopoietic differentiation.

UVB mutagenesis differs in NRAS- and BRAF-mutant mouse models of melanoma

This study compares UVB mutagenesis effects in NRAS- and BRAF-mutant mouse melanoma models, finding BRAF-mutant tumors have more mutations and a stronger UVB mutational signature.

Leukemia cell of origin influences apoptotic priming and sensitivity to LSD1 inhibition

This study shows that leukemia cell of origin affects apoptotic priming and sensitivity to LSD1 inhibitors, with Evi1 modulating p53 stability and activity.

Single cell mutational profiling delineates clonal trajectories in myeloid malignancies

This study uses single-cell mutational profiling to analyze clonal trajectories in myeloid malignancies, revealing patterns of mutation acquisition and clonal complexity.

Stag1 and Stag2 regulate cell fate decisions in hematopoiesis through non-redundant topological control

The paper shows Stag2 loss in HSPCs impairs B-cell lineage commitment by reducing chromatin accessibility, while Stag1 cannot restore this function despite rescuing topological domains.

Isoform switching as a mechanism of acquired resistance to isocitrate dehydrogenase inhibition

The paper identifies isoform switching between mutant IDH1 and IDH2 as a mechanism of acquired resistance to IDH inhibitors in cancers.