Author

L. Alexandrescu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

S. White· 3 shared J. Calabrese· 2 shared R. Kejriwal· 2 shared D. J. Rowlands· 1 shared D. Jacobs-Sera· 1 shared D. Olson· 1 shared G. Hatfull· 1 shared G. Murali· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersPharmacology & Toxicology

S. White

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Development of Enterovirus anti-viral agents that target the viral 2C protein

R. Kejriwal, T. Evans, J. Calabrese, L. Swistak, L. Alexandrescu, M. Cohen, N. Rahman, N. Henriksen, R. C. Dash, K. Hadden, N. J. Stonehouse, D. J. Rowlands, N. J. Kingston, M. Hartnoll, S. Dobson, S. White

This study develops broad-spectrum anti-viral compounds targeting the conserved EV 2C protein, showing low IC50 values and suggesting a role for 2C in capsid assembly.

bioRxiv · Oct 6, 2022Pharmacology & Toxicology

Isolating Compounds that Inhibit EV 71 Virus

G. Murali, R. Kejriwal, D. Olson, L. Alexandrescu, S. White

This study tests 364 drugs to find inhibitors of EV 71 virus, identifying a combination of Mitrofudil and N6-Benzyladenosine that stops ATPase activity, suggesting potential antiviral effects.

bioRxiv · Jul 30, 2020 · PreprintCell Biology

Structures of three actinobacteriophage capsids: Roles of symmetry and accessory proteins

J. Podgorski, J. Calabrese, L. Alexandrescu, D. Jacobs-Sera, W. Pope, G. Hatfull, S. White

The paper describes the structures of three actinobacteriophage capsids, confirming the use of the HK97-fold and identifying novel accessory proteins involved in capsid formation.

bioRxiv · Jan 21, 2020Microbiology