M. Cohen

Impaired Myofibroblast Proliferation is a Central Feature of Pathologic Post-Natal Alveolar Simplification

This study identifies impaired myofibroblast proliferation as a central feature of alveolar simplification in BPD using single-cell RNA sequencing and pharmacologic approaches.

Pre-existing interferon gamma conditions the lung to mediate early control of SARS-CoV-2

This study shows that pre-existing IFN-gamma responses from bacterial infection reduce SARS-CoV-2 viral loads in the lungs and protect against disease in mice.

Development of Enterovirus anti-viral agents that target the viral 2C protein

This study develops broad-spectrum anti-viral compounds targeting the conserved EV 2C protein, showing low IC50 values and suggesting a role for 2C in capsid assembly.

Identification and Mechanistic Basis of non-ACE2 Blocking Neutralizing Antibodies from COVID-19 Patients with Deep RNA Sequencing and Molecular Dynamics Simulations

The paper identifies non-ACE2 blocking neutralizing antibodies in COVID-19 patients using deep RNA sequencing and molecular dynamics simulations, showing their potential for personalized therapy.

Invariant Representation of Physical Stability in the Human Brain

The paper investigates whether the brain or CNNs use invariant representations for physical stability judgments and finds such representations in fronto-parietal regions but not in the ventral visual pathway.

Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants

This study identifies ultrapotent bispecific antibodies that neutralize emerging SARS-CoV-2 variants by targeting multiple spike protein regions, showing efficacy in vitro and in a hamster model.

Locally-invasive, castrate-resistant prostate cancer in a Pten/Trp53 double knockout mouse model of prostate cancer monitored with non-invasive bioluminescent imaging

The paper improves a prostate cancer mouse model with a bioluminescent reporter to monitor tumor progression and shows that double knockout of Pten and Trp53 leads to castrate-resistant, locally invasive tumors.

Linking endoplasmic reticulum stress to polyploidy in ovarian cancer cells

This study links endoplasmic reticulum stress to polyploidy in ovarian cancer cells by showing UPR activation promotes cell fusion and PGCC formation, with PERK involvement.

Cell cycle oscillators underlying orderly proteolysis of E2F8

The paper investigates the mechanisms controlling E2F8 dynamics during the cell cycle using cell-free systems, revealing phosphorylation, ubiquitination, and transcriptional regulation.