S. White

Microbial aerotrophy enables continuous primary production in diverse cave ecosystems

This study identifies aerotrophy as a primary energy source in caves, revealing microbial use of atmospheric trace gases for continuous primary production.

Gene editing of pigs to control influenza A virus infections

This study edits pigs to knock out TMPRSS2, reducing influenza A virus replication and shedding, with implications for controlling IAV in pigs.

Characterization of DSPE-mPEG raw materials from different vendors reveals differences in impurity profiles and polymer chain length polydispersity

The paper analyzes DSPE-mPEG raw materials from different vendors, finding variations in impurity profiles and polymer chain length polydispersity using mass spectrometry.

The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming

This study shows that chemotherapy-induced senescence-associated secretome promotes metastasis in ovarian cancer by reprogramming metabolism and increasing cell detachment.

Foodscapes for Salmon and Other Mobile Consumers in River Networks

The paper introduces the concept of 'foodscapes' to describe how food abundance, accessibility, and foraging costs vary in river networks, affecting fish growth and population stability.

Development of Enterovirus anti-viral agents that target the viral 2C protein

This study develops broad-spectrum anti-viral compounds targeting the conserved EV 2C protein, showing low IC50 values and suggesting a role for 2C in capsid assembly.

The wild life of ticks: using passive surveillance to determine the distribution and wildlife host range of ticks and the exotic Haemaphysalis longicornis, 2010-2021

This study used passive wildlife surveillance to collect tick data across the eastern U.S., identifying the distribution of exotic H. longicornis and other tick species, and generating new county reports for several important tick species.

HSV Tegument Protein pUL51 Interacts with Host Dynactin for Viral Spread

This study identifies an interaction between HSV-1 protein pUL51 and host dynactin subunit p150Glued, essential for viral spread, and shows that disrupting this interaction inhibits HSV growth and spread.

SARS-CoV-2 expresses a microRNA-like small RNA able to selectively repress host genes

This study identifies a viral miRNA-like small RNA, vmiR-5p, from SARS-CoV-2 that represses host genes through the RNA interference pathway.

Characterization of the gene repertoire and environmentally driven expression patterns in Tanner crab (Chionoecetes bairdi)

This study characterizes the gene repertoire and temperature-driven expression patterns in Tanner crab infected with Hematodinium, revealing insights into energy allocation and morphological changes under different thermal conditions.

A two-year study on the phenology, host and habitat associations, and pathogens of Haemaphysalis longicornis in Virginia, U.S.A.

This study tracks Haemaphysalis longicornis phenology, host associations, and pathogens in Virginia over two years, finding year-round nymphal activity and novel host and pathogen associations.

Comparing instance segmentation methods for analyzing clonal growth of single cells in microfluidic chips

The paper compares segmentation methods for analyzing clonal growth in microfluidic chips, finding unsupervised learning methods more accurate and flexible than supervised approaches.

Ecology and Epidemiology of Wheat Curl Mite and Mite-Transmissible Viruses in Colorado and Insights into the Wheat Virome

The paper analyzes genetic variability in wheat curl mites and mite-transmissible viruses in Colorado, identifies resistance sources in wheat germplasm, and finds variation in virus resistance among wheat varieties.

Isolating Compounds that Inhibit EV 71 Virus

This study tests 364 drugs to find inhibitors of EV 71 virus, identifying a combination of Mitrofudil and N6-Benzyladenosine that stops ATPase activity, suggesting potential antiviral effects.

HSV Forms an HCMV-like Viral Assembly Center in Neuronal Cells

This study shows HSV forms a distinct viral assembly center in neuronal cells, concentrating viral proteins and host membranes, and depends on microtubules and pUL51.

Structures of three actinobacteriophage capsids: Roles of symmetry and accessory proteins

The paper describes the structures of three actinobacteriophage capsids, confirming the use of the HK97-fold and identifying novel accessory proteins involved in capsid formation.

Geldanamycin inhibits Jumonji histone lysine demethylase KDM4 and targets chimeric transcription factor PAX3-FOXO1

This study identifies geldanamycin and its analog 17-DMAG as dual KDM/Hsp90 inhibitors effective against PAX3-FOXO1-driven rhabdomyosarcoma.

The C-terminal tail of the bacterial translocation ATPase SecA modulates its activity

This study investigates how the C-terminal tail of SecA modulates its activity in cotranslational substrate protein recognition by interacting with ribosomes and substrate proteins.

A novel bioreactor technology for modelling fibrosis in human and rodent precision-cut liver slices.

This paper develops a bioreactor system that extends the viability of precision-cut liver slices (PCLS) to 6 days under normoxic conditions and demonstrates its use in modeling fibrogenesis and testing anti-fibrotic drugs.