N. Rahman

Rapid differentiation of estrogen receptor status in patient biopsy breast cancer aspirates with an optical nanosensor

This paper develops an optical nanosensor using carbon nanotubes to rapidly detect estrogen receptor status in breast cancer biopsies with high accuracy.

Human vaginal microbiota colonization is regulated by female sex 1 hormones in a mouse model

This study shows that female sex hormones regulate vaginal microbiota colonization in mice, with estrogen promoting bacterial persistence and glycogen production.

Optical nanosensor passivation enables highly sensitive detection of the inflammatory cytokine IL-6

The paper develops a passivated optical nanosensor for IL-6 detection, achieving high sensitivity and specificity in human serum.

A mathematical model for axonal transport of large cargo vesicles

The paper develops a mathematical model to study the dynamics of axonal transport of large cargo vesicles interacting with the membrane-associated periodic cytoskeletal structure.

Inhibiting ribosome assembly and ribosome translation have distinctly different effects on the abundance and paralogue composition of ribosomal protein mRNAs in Saccharomyces cerevisiae

The paper shows that inhibiting ribosome assembly and ribosome translation differently affect ribosomal protein mRNA abundance and paralogue composition in yeast.

Development of Enterovirus anti-viral agents that target the viral 2C protein

This study develops broad-spectrum anti-viral compounds targeting the conserved EV 2C protein, showing low IC50 values and suggesting a role for 2C in capsid assembly.

RNA helicase DDX5 mediates adaptive response to multi-kinase inhibitors in liver cancer

This study shows that mTKIs like sorafenib downregulate DDX5, leading to activation of Wnt/β-catenin and non-canonical NF-κB pathways, which enable ferroptosis escape and mTKI resistance in liver cancer.

Plasma cell maintenance and antibody secretion are under the control of Sec22b-mediated regulation of organelle dynamics

This study identifies Sec22b as a critical regulator of plasma cell maintenance and function by controlling organelle dynamics, leading to reduced antibody secretion and impaired immune response.

The serogroup B meningococcal outer membrane vesicle-based vaccine 4CMenB induces cross-species protection against Neisseria gonorrhoeae

This paper demonstrates that the 4CMenB vaccine, based on Neisseria meningitidis outer membrane vesicles, provides cross-species protection against Neisseria gonorrhoeae in a mouse model, with antibodies targeting several surface proteins.

A systematic mutational analysis identifies a 5-residue proline tag that enhances the in vivo immunogenicity of a non-immunogenic model protein 240 folds

Generation of nanometer-size aggregates using Solubility Controlling Peptide tags and their ability to increase a proteins immunogenicity in vivo

This study shows that nanometer-scale protein aggregates can increase immunogenicity in vivo, using BPTI-19A as a model.