Author

L. Altucci

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

G. Franci· 2 shared R. Benedetti· 2 shared A. Chambery· 1 shared A. D'Aniello· 1 shared A. De Filippis· 1 shared A. Dolnik· 1 shared A. J. Cesare· 1 shared A. P. Sobinoff· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersMicrobiology

G. Franci

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Irreversible inhibition of TRF2TRFH recruiting functions: a strategy to induce telomeric replication stress in cancer cells.

A. P. Sobinoff, S. Di Maro, R. R. J. Low, R. Benedetti, S. Tomassi, A. D'Aniello, R. Russo, I. Baglivo, U. Chianese, P. V. Pedone, A. Chambery, A. J. Cesare, L. Altucci, H. A. Pickett, S. Cosconati

This paper identifies APOD53, a covalent cyclic peptide that irreversibly inhibits TRF2TRFH domain function, inducing telomeric replication stress and impairing cancer cell growth.

bioRxiv · Feb 1, 2023 · PreprintCancer Biology

Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia

Y. Zhai, P. Singh, A. Dolnik, P. Brazda, N. Atlasy, N. del Gaudio, K. Dohner, H. Dohner, S. Minucci, J. Martens, L. Altucci, W. Megchelenbrink, L. Bullinger, H. G. Stunnenberg

This study uses longitudinal single-cell transcriptomics to analyze AML recurrence patterns, finding varying transcriptional changes between diagnosis and relapse that challenge the clonal evolution model.

bioRxiv · Jan 4, 2022 · PreprintCancer Biology

Outer membrane vesicles derived from Klebsiella pneumoniae are a driving force for horizontal gene transfer

F. Dell'Annunziata, C. DellAversana, N. Doti, G. Donadio, F. Dal Piaz, V. Izzo, A. De Filippis, M. Galdiero, L. Altucci, G. Boccia, M. Galdiero, V. Folliero, G. Franci

This study shows that Klebsiella pneumoniae outer membrane vesicles facilitate horizontal gene transfer of plasmids containing resistance genes, with transfer efficiency dependent on plasmid copy number and effective across multiple species.

bioRxiv · Jul 6, 2021Microbiology

DNA Mutations via Chern-Simons Current

F. Bajardi, L. Altucci, R. Benedetti, S. Capozziello, M. R. Del Sorbo, G. Franci, C. Altucci

The paper uses Chern-Simons theory to analyze DNA curvature and mutation positions in KRAS and COVID-19 sequences, finding mutations correlate with high curvature gradients and smoother post-mutation curvature.

bioRxiv · Jun 22, 2021Biophysics