Author

L. Bullinger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:DNA methylation· 1

Frequent Co-Authors

A. Dolnik· 2 shared A. H. Porter· 1 shared A. Merlotti· 1 shared A. Oestlund· 1 shared A. P. Sobinoff· 1 shared A. Riedel· 1 shared A. Song· 1 shared A. T. Turki· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCancer Biology

A. Dolnik

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Author profile →

4 papers

Recent·Most cited

Altered enhancer-promoter interaction leads to MNX1 expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13)

D. Weichenhan, A. Riedel, E. Sollier, U. H. Toprak, J. Hey, K. Breuer, J. A. Wierzbinska, A. Touzart, P. Lutsik, M. Baehr, A. Oestlund, C. Nilsson, S. Jacobsson, M. Edler, A. Waraky, , C. Plass

The paper shows MNX1 overexpression in t(7;12)(q36;p13) AML is due to enhancer hijacking, not oncofusion, and is common in pediatric cases.

bioRxiv · Sep 13, 2023 · PreprintCancer Biology

Covering Hierarchical Dirichlet Mixture Models on binary data to enhance genomic stratifications in Onco-Hematology

D. Dall'Olio, E. Sträng, A. T. Turki, J. M. Tettero, M. Barbus, R. Schulze-Rath, J. M. Elicegui, T. Matteuzzi, A. Merlotti, L. Carota, C. Sala, M. G. Della Porta, E. Giampieri, J. M. Hernandez-Rivas, L. Bullinger, G. Castellani

This paper applies Hierarchical Dirichlet Mixture Models to binary genomic data in AML to improve patient stratification and clustering through statistical refinements.

bioRxiv · Jun 26, 2023Cancer Biology

Imetelstat-Mediated Alterations in Fatty Acid Metabolism To Induce Ferroptosis As Therapeutic Strategy for Acute Myeloid Leukemia

C. Bruedigam, A. H. Porter, A. Song, G. Vroeg in de Wei, T. Stoll, J. Straube, L. Cooper, G. Cheng, V. F. S. Kahl, A. P. Sobinoff, V. Y. Ling, B. M. C. Jebaraj, Y. Janardhanan, R. Haldar, L. J. Bray, , S. W. Lane

This study identifies ferroptosis as a mechanism by which imetelstat induces therapeutic effects in AML, showing that targeting fatty acid metabolism enhances its efficacy.

bioRxiv · Apr 25, 2023Cancer Biology

Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia

Y. Zhai, P. Singh, A. Dolnik, P. Brazda, N. Atlasy, N. del Gaudio, K. Dohner, H. Dohner, S. Minucci, J. Martens, L. Altucci, W. Megchelenbrink, L. Bullinger, H. G. Stunnenberg

This study uses longitudinal single-cell transcriptomics to analyze AML recurrence patterns, finding varying transcriptional changes between diagnosis and relapse that challenge the clonal evolution model.

bioRxiv · Jan 4, 2022 · PreprintCancer Biology