A. J. Cesare

Homologous recombination promotes mitotic death to suppress the innate immune response

The paper shows that homologous recombination (HR) promotes mitotic death, which suppresses the innate immune response by preventing immunogenic cell death.

Nuclear actin and DNA replication stress regulate the recruitment of human telomerase to telomeres

The paper shows that nuclear actin and replication stress regulate telomerase recruitment to telomeres via ATR and mTOR, enabling telomere length maintenance in human cells.

Irreversible inhibition of TRF2TRFH recruiting functions: a strategy to induce telomeric replication stress in cancer cells.

This paper identifies APOD53, a covalent cyclic peptide that irreversibly inhibits TRF2TRFH domain function, inducing telomeric replication stress and impairing cancer cell growth.

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.

This study identifies PLK1 as a target of EYA4 and EYA1 phosphatases, showing that dephosphorylation of pY445 promotes PLK1 activation and mitosis, with implications for cancer therapy.

Critical role for cold shock protein YB-1 in cytokinesis

This study identifies YB-1's role in cytokinesis by showing its necessity for microtubule organization and phosphorylation-dependent function.

ATR and mTOR regulate F-actin to alter nuclear architecture and repair replication stress

Phasor histone FLIM-FRET microscopy quantifies spatiotemporal rearrangement of chromatin architecture during the DNA damage response.

The paper develops a biophysical method to quantify chromatin compaction dynamics during DNA damage response using FLIM-FRET microscopy and identifies roles of ATM and RNF8 in chromatin reorganization.