Cancer BiologybioRxivPreprint
Irreversible inhibition of TRF2TRFH recruiting functions: a strategy to induce telomeric replication stress in cancer cells.
A. P. Sobinoff, S. Di Maro, R. R. J. Low…·S. Cosconati
This paper identifies APOD53, a covalent cyclic peptide that irreversibly inhibits TRF2TRFH domain function, inducing telomeric replication stress and impairing cancer cell growth.
DOI 10.1101/2023.02.01.526591