Glutathionylation of Pyruvate Dehydrogenase Complex E2 and Inflammatory Cytokine Production During Acute Inflammation Are Magnified By Mitochondrial Oxidative Stress
D. L. Long, C. E. McCall, L. B. Poole
This study shows that LPS-induced glutathionylation of PDCE2 in monocytes increases ROS production and alters cytokine profiles, with synergistic effects when combined with mitochondrial oxidative stress.
bioRxiv · Jan 26, 2023Immunology