Author

L. Bardwell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

A. J. Bardwell· 2 shared B. Wu· 1 shared D. A. Fruman· 1 shared K. C. Yoneda· 1 shared K. Y. Sarin· 1 shared M. D. Andrade-Ludena· 1 shared M. L. Waterman· 1 shared M. Paul· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

A. J. Bardwell

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2 papers

Recent·Most cited

The WW domain of IQGAP1 binds directly to the p110α catalytic subunit of PI 3-kinase

A. J. Bardwell, M. Paul, K. C. Yoneda, M. D. Andrade-Ludena, O. T. Nguyen, D. A. Fruman, L. Bardwell

This study identifies the direct interaction between the WW domain of IQGAP1 and the p110α catalytic subunit of PI3K, revealing key residues involved in binding and implications for therapeutic peptide design.

bioRxiv · Sep 24, 2022Biochemistry

ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1

A. J. Bardwell, B. Wu, K. Y. Sarin, M. L. Waterman, S. X. Atwood, L. Bardwell

This study shows that ERK2 phosphorylates GLI1 at three sites, weakening its binding to SUFU and enhancing GLI1 activation, contributing to Hedgehog-MAPK pathway crosstalk in cancer.

bioRxiv · Dec 22, 2021Cell Biology