Author

M. L. Waterman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

G. T. Chen· 2 shared A. J. Bardwell· 1 shared A. Mortazavi· 1 shared A. P. Lee· 1 shared A. Tankazyan· 1 shared B. Wu· 1 shared C. C. Hughes· 1 shared D. A. Lawson· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

G. T. Chen

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Author profile →

3 papers

Recent·Most cited

ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1

A. J. Bardwell, B. Wu, K. Y. Sarin, M. L. Waterman, S. X. Atwood, L. Bardwell

This study shows that ERK2 phosphorylates GLI1 at three sites, weakening its binding to SUFU and enhancing GLI1 activation, contributing to Hedgehog-MAPK pathway crosstalk in cancer.

bioRxiv · Dec 22, 2021Cell Biology

An In Vitro Vascularized Micro-Tumor Model of Human Colorectal Cancer Recapitulates In Vivo Drug Responses

S. J. Hachey, S. Movsesyan, Q. H. Nguyen, G. Burton-Sojo, A. Tankazyan, J. Wu, T. Hoang, M. M. Hatch, D. Zhao, E. Celaya, S. Gomez, G. T. Chen, R. T. Davis, K. Nee, N. Pervolarakis, , C. C. Hughes

This paper validates a vascularized micro-tumor model for colorectal cancer that better replicates in vivo drug responses than traditional 2D or 3D models.

bioRxiv · Mar 3, 2020Cancer Biology

Disrupting β-catenin dependent Wnt signaling activates an invasive gene program predictive of colon cancer progression

G. T. Chen, D. F. Tifrea, R. Murad, Y. Lyou, A. Mortazavi, R. A. Edwards, M. L. Waterman

This study shows that reducing Wnt signaling in colon cancer cells increases their invasiveness and identifies gene markers predictive of poor patient outcomes.

bioRxiv · Jul 16, 2019Cancer Biology