Author

D. A. Fruman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Bolgioni-Smith· 1 shared A. J. Bardwell· 1 shared A. L. Hillis· 1 shared A. M. Brown· 1 shared A. Mathur· 1 shared A. Toker· 1 shared A. Van Wart· 1 shared B. Bowden· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperScientific Communication & Education

A. Bolgioni-Smith

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cholesterol biosynthesis inhibition synergizes with AKT inhibitors in triple-negative breast cancer

A. Toker, A. L. Hillis, T. D. Martin, H. E. Manchester, J. M. Hogstrom, N. Zhang, E. Lecky, N. Kozlova, N. S. Persky, D. E. Root, M. Brown, K. Cichowski, S. J. Elledge, T. Muranen, D. A. Fruman, , R. R. Madsen

This study identifies a synergistic effect between AKT inhibitors and pitavastatin in killing triple-negative breast cancer cells by targeting cholesterol trafficking.

bioRxiv · Jan 16, 2024 · PreprintCancer Biology

The WW domain of IQGAP1 binds directly to the p110α catalytic subunit of PI 3-kinase

A. J. Bardwell, M. Paul, K. C. Yoneda, M. D. Andrade-Ludena, O. T. Nguyen, D. A. Fruman, L. Bardwell

This study identifies the direct interaction between the WW domain of IQGAP1 and the p110α catalytic subunit of PI3K, revealing key residues involved in binding and implications for therapeutic peptide design.

bioRxiv · Sep 24, 2022Biochemistry

Measuring effects of trainee professional development on research productivity: A cross-institutional meta-analysis

P. Brandt, S. Sturzenegger Varvayanis, T. Baas, A. Bolgioni-Smith, J. Alder, K. A. Petrie, I. Dominguez, A. M. Brown, C. A. Stayart, H. Singh, A. Van Wart, C. S. Chow, A. Mathur, B. M. Schreiber, D. A. Fruman, , R. Layton

This study analyzes the impact of professional development programs on doctoral students' research productivity and time to degree across ten institutions, finding no negative effects and some positive correlations.

bioRxiv · Sep 28, 2020 · PreprintScientific Communication & Education