Hematopoietic stem cells fail to regenerate following inflammatory challenge.
R. Bogeska, P. Kaschutnig, M. Fawaz, A.-M. Mikecin, M. Buechler-Schaeff, S. Paffenholz, N. Asada, F. Frauhammer, F. Buettner, M. Ball, J. Knoch, S. Staeble, D. Walter, A. Petri, M. J. Carreno-Gonzalez, , M. D. Milsom
This study shows that repeated inflammatory challenges lead to progressive depletion of functional HSCs with no recovery, contributing to age-related hematopoietic decline.
bioRxiv · Aug 1, 2020Cell Biology