Author

L. Borrega-Roman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:proteomics· 1

Frequent Co-Authors

C. Salanga· 2 shared I. Kufareva· 2 shared S. Gu· 2 shared A. J. Tebben· 1 shared A. Lona· 1 shared D. J. Gonzalez· 1 shared G. M. Wadman· 1 shared J. R. D. Dawson· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersPharmacology & Toxicology

C. Salanga

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Author profile →

2 papers

Recent·Most cited

Molecular determinants of antagonist interactions with chemokine receptors CCR2 and CCR5

J. R. D. Dawson, G. M. Wadman, P. Zhang, A. J. Tebben, P. H. Carter, S. Gu, T. Shroka, L. Borrega-Roman, C. Salanga, T. M. Handel, I. Kufareva

This study identifies molecular determinants of CCR2 and CCR5 antagonist interactions using docking and AI screening, revealing structural principles and selectivity mechanisms.

bioRxiv · Nov 15, 2023 · PreprintPharmacology & Toxicology

Ligand-Dependent Mechanisms of C-C Chemokine Receptor 5 (CCR5) Trafficking Revealed by APEX2 Proximity Labeling Proteomics

S. Gu, S. Maurya, A. Lona, L. Borrega-Roman, C. Salanga, D. J. Gonzalez, I. Kufareva, T. Handel

This study uses APEX2 proximity labeling and mass spectrometry to uncover ligand-dependent CCR5 trafficking mechanisms, revealing distinct internalization and degradation pathways.

bioRxiv · Nov 1, 2023 · PreprintCell Biology