Author

D. J. Gonzalez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cell Biology· 2 Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2

Frequent Co-Authors

D. McGrosso· 3 shared A. Campeau· 2 shared S. Maurya· 2 shared A. Agelidis· 1 shared A. C. Newton· 1 shared A. Lona· 1 shared A. M. O'Neill· 1 shared A. P. Kornev· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

D. McGrosso

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Proteome profiling identifies a link between the mitochondrial pathways and host-microbial sensor ELMO1 following Salmonella infection.

S. Achi, D. McGrosso, S. Tocci, S.-R. Ibeawuchi, I. M. Sayed, D. J. Gonzalez, S. Das

This study identifies a link between ELMO1 and mitochondrial pathways in macrophages during Salmonella infection through proteome profiling and functional analysis.

bioRxiv · May 3, 2024 · PreprintMicrobiology

Ligand-Dependent Mechanisms of C-C Chemokine Receptor 5 (CCR5) Trafficking Revealed by APEX2 Proximity Labeling Proteomics

S. Gu, S. Maurya, A. Lona, L. Borrega-Roman, C. Salanga, D. J. Gonzalez, I. Kufareva, T. Handel

This study uses APEX2 proximity labeling and mass spectrometry to uncover ligand-dependent CCR5 trafficking mechanisms, revealing distinct internalization and degradation pathways.

bioRxiv · Nov 1, 2023 · PreprintCell Biology

A bacterial sialidase mediates early life colonization by a pioneering gut commensal

E. Buzun, C.-Y. Hsu, K. Sejane, R. E. Oles, A. V. Ayala, L. R. Loomis, J. Zhao, L.-A. Rossitto, D. McGrosso, D. J. Gonzalez, L. Bode, H. Chu

This study identifies a bacterial sialidase, NanH, in Bacteroides fragilis that mediates early gut colonization and resilience through host-derived glycans.

bioRxiv · Aug 8, 2023Microbiology

Proteome allocation is linked to transcriptional regulation through a modularized transcriptome

A. Patel, D. McGrosso, Y. Hefner, A. Campeau, A. V. Sastry, S. Maurya, K. Rychel, D. J. Gonzalez, B. O. Palsson

The paper investigates modularization of bacterial transcriptomes and proteomes to uncover relationships between their compositions and regulatory mechanisms.

bioRxiv · Feb 20, 2023Bioengineering

Protein Kinase C gamma Mutations Drive Spinocerebellar Ataxia Type 14 by Impairing Autoinhibition

C. A. Pilo, T. R. Baffi, A. P. Kornev, M. T. Kunkel, M. Malfavon, D.-H. Chen, L.-C. Huang, C. Longman, N. A. Kannan, W. H. Raskind, D. J. Gonzalez, S. S. Taylor, G. Gorrie, A. C. Newton

SCA14 driver mutations in PKCγ impair autoinhibition, with defect correlating inversely with age of disease onset.

bioRxiv · Jun 24, 2021 · PreprintBiochemistry

Antimicrobials from a feline commensal bacterium inhibit skin infection by drug-resistant S. pseudintermedius.

A. M. O'Neill, K. A. Worthing, N. Kulkarni, F. Li, T. Nakatsuji, R. H. Mills, J. Y. Cheng, D. J. Gonzalez, J. M. Norris, R. L. Gallo

This study identifies a feline commensal bacterium, S. felis, that inhibits drug-resistant S. pseudintermedius through antimicrobial peptides, showing potential for bacteriotherapy against skin infections.

bioRxiv · Mar 8, 2021Microbiology

Disruption of innate defense responses by endoglycosidase HPSE promotes cell survival

A. Agelidis, B. A. Turturice, R. K. Suryawanshi, T. Yadavalli, D. Jaishankar, J. Ames, J. Hopkins, L. Koujah, C. D. Patil, S. R. Hadigal, E. J. Kyzar, A. Campeau, J. M. Wozniak, D. J. Gonzalez, I. Vlodavsky, , D. Shukla

This study shows that HPSE disrupts innate defense responses, promoting cell survival during HSV-1 infection by inhibiting cell-intrinsic defenses and facilitating host cell reprogramming.

bioRxiv · Aug 5, 2020Cell Biology