L. Maegdefessel

The aging-induced long non-coding RNA MIRIAL controls endothelial cell and mitochondrial function

This paper identifies MIRIAL as an aging-induced lncRNA that regulates endothelial quiescence and mitochondrial function through a novel triplex mechanism.

Loss of myeloid cannabinoid CB1 receptor confers atheroprotection by reducing macrophage proliferation and immunometabolic reprogramming

This study shows that loss of myeloid CB1 receptor reduces atherosclerosis in male mice by limiting macrophage proliferation and inflammation, with sex-specific effects observed.

PI 3-kinase isoform p110α mediated FOXO1 inactivation protects against aortic aneurysm formation

This study shows that p110α-mediated FOXO1 inactivation in smooth muscle cells prevents aortic aneurysm formation by maintaining vascular homeostasis and promoting reparative SMC phenotypes.

The lncRNA landscape of cardiac resident macrophages and identification of Schlafenlnc as a regulator of macrophage migratory function

The paper identifies lncRNAs in cardiac resident macrophages and shows Schlafenlnc regulates macrophage migration.

Utilization of an Artery-on-a-chip to unravel novel regulators and therapeutic targets in vascular diseases

The paper develops an artery-on-a-chip model to study shear stress effects on vascular diseases and identifies novel therapeutic targets.

Aging-regulated TUG1 is dispensable for endothelial cell function

This study shows that TUG1, despite high expression and conservation, does not significantly affect endothelial cell function in vitro.

MIF-2/D-DT is an atypical atherogenic chemokine that promotes advanced atherosclerosis and hepatic lipogenesis

This study identifies MIF-2 as an atherogenic chemokine that promotes atherosclerosis and hepatic lipogenesis by acting through CXCR4 and SREBP pathways.

GPR55 in B cells limits atherosclerosis development and regulates plasma cell maturation

This study shows that GPR55 in B cells reduces atherosclerosis by regulating plasma cell maturation and antibody production.

Heterocomplexes between the Atypical Chemokine MIF and the CXC-Motif Chemokine CXCL4L1 Regulate Inflammation and Thrombus Formation

This study identifies a novel interaction between the atypical chemokine MIF and the CXC-motif chemokine CXCL4L1, showing that their heterocomplex formation modulates inflammation and thrombus formation.