Author

L. Castellano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:C. elegans· 1 Research Focus:ecology & biodiversity· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Blair· 1 shared A. Galimberti· 1 shared A. Goff· 1 shared A. JoachimiakiD· 1 shared B. P. Towler· 1 shared D. T. Nguyen· 1 shared E. Chuang· 1 shared E. Gomes· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCell Biology

A. Blair

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

β-Catenin associates with a Wnt signaling mRNA network in myeloid cells through canonical RBP binding.

M. Wagstaff, O. Sevim, A. Goff, M. Raynor, H. Park, E. Mancini, D. T. Nguyen, T. Chevassut, A. Blair, L. Castellano, S. F. Newbury, B. P. Towler, R. G. Morgan

The paper identifies β-catenin-associated mRNAs in myeloid cells through RIP-seq and shows MSI2 interacts with LEF1 mRNA, regulating Wnt signaling and HSPC expansion.

bioRxiv · Jan 28, 2024 · PreprintCell Biology

CRISPR screens in 3D tumourspheres identified miR-4787-3p as a transcriptional start site miRNA essential for breast tumour-initiating cell growth

T. Stiff, S. Bayraktar, P. Dama, J. Stebbing, L. Castellano

The paper identifies miR-4787-3p as an essential miRNA for breast tumor-initiating cell growth using CRISPR screens and validates its role as a potential therapeutic target and prognostic biomarker.

bioRxiv · Dec 6, 2023 · PreprintCell Biology

Therapeutic genetic variation revealed in diverse Hsp104 homologs

Z. March, K. Sweeney, H. Kim, X. Yan, L. Castellano, M. Jackrel, E. Chuang, E. Gomes, K. Michalska, R. Jedrzejczak, A. Joachimiak, K. Caldwell, G. Caldwell, O. Shalem, J. Shorter

The paper identifies therapeutic genetic variations in Hsp104 homologs that specifically counter proteotoxicity in yeast, human cells, and C. elegans by enhancing passive chaperone activity.

bioRxiv · Mar 25, 2020Biochemistry

Novel Universal Primers For Metabarcoding eDNA Surveys Of Marine Mammals And Other Marine Vertebrates

E. Valsecchi, J. Bylemans, S. J. Goodman, R. Lombardi, I. Carr, L. Castellano, A. Galimberti, P. Galli

The paper develops and validates new universal primers for metabarcoding eDNA to survey marine vertebrates, showing improved taxonomic resolution across multiple species.

bioRxiv · Sep 5, 2019Ecology