Therapeutic genetic variation revealed in diverse Hsp104 homologs
Z. March, K. Sweeney, H. Kim, X. Yan, L. Castellano, M. Jackrel, E. Chuang, E. Gomes, K. Michalska, R. Jedrzejczak, A. Joachimiak, K. Caldwell, G. Caldwell, O. Shalem, J. Shorter
The paper identifies therapeutic genetic variations in Hsp104 homologs that specifically counter proteotoxicity in yeast, human cells, and C. elegans by enhancing passive chaperone activity.
bioRxiv · Mar 25, 2020Biochemistry