Author

O. Shalem

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 3 Organism:C. elegans· 2 Approach:deep learning· 2 Approach:genetic perturbation / CRISPR· 2 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

G. M. Burslem· 2 shared Y. V. Serebrenik· 2 shared A. Alcala· 1 shared A. JoachimiakiD· 1 shared C. H. June· 1 shared C. K. Tsui· 1 shared C. R. Good· 1 shared D. Mani· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersCell Biology

G. M. Burslem

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Author profile →

5 papers

Recent·Most cited

Pooled tagging and hydrophobic targeting of endogenous proteins for unbiased mapping of unfolded protein responses

S. E. Sansbury, Y. V. Serebrenik, T. Lapidot, G. M. Burslem, O. Shalem

The paper develops a method to map unfolded protein responses by tagging endogenous proteins and analyzing their localization and stress responses using single-cell RNA sequencing.

bioRxiv · Jul 13, 2023Cell Biology

Pooled endogenous protein tagging and recruitment for scalable discovery of effectors for induced proximity therapeutics

Y. V. Serebrenik, D. Mani, T. Maujean, G. M. Burslem, O. Shalem

This paper introduces a method to systematically discover effector proteins for induced proximity therapeutics by combining high-throughput endogenous protein tagging with small molecule-based recruitment.

bioRxiv · Jul 13, 2023Cell Biology

Large-scale genetic screens identify BET-1 as a cytoskeleton regulator promoting actin health and lifespan.

G. Garcia, R. Bar-Ziv, N. Dutta, D. Moaddeli, M. Averbukh, T. C. Torres, A. Alcala, C. K. Tsui, E. A. Moehle, O. Shalem, M. Thorwald, R. Higuchi-Sanabria

The paper identifies BET-1 as a regulator of actin health and lifespan through genetic screens in human fibroblasts and C. elegans.

bioRxiv · Jun 22, 2022 · PreprintCell Biology

Therapeutic genetic variation revealed in diverse Hsp104 homologs

Z. March, K. Sweeney, H. Kim, X. Yan, L. Castellano, M. Jackrel, E. Chuang, E. Gomes, K. Michalska, R. Jedrzejczak, A. Joachimiak, K. Caldwell, G. Caldwell, O. Shalem, J. Shorter

The paper identifies therapeutic genetic variations in Hsp104 homologs that specifically counter proteotoxicity in yeast, human cells, and C. elegans by enhancing passive chaperone activity.

bioRxiv · Mar 25, 2020Biochemistry

Impaired tumor death receptor signaling drives resistance to CAR T cell therapy

N. Singh, O. Shestova, P. Ravikumar, K. Hayer, S. J. Hong, E. J. Orlando, K. T. Mueller, C. R. Good, S. L. Berger, O. Shalem, M. D. Weitzman, S. A. Grupp, C. H. June, S. Gill, M. Ruella

This study identifies impaired death receptor signaling as a driver of resistance to CAR T cell therapy in B-cell leukemia by showing its role in tumor survival and T cell dysfunction.

bioRxiv · May 5, 2019 · PreprintImmunology