A. Joachimiak

The paper reports a cryo-EM structure of detergent-bound Vibrio cholerae MakA, revealing its conformational changes and role in pore assembly.

PANCS-spec-Binders rapidly identifies binders with defined specificity by combining selection and counterselection to target specific isoforms or epitopes.

The paper introduces a funnel approach to identify epitope-specific CD4 T cells for influenza and SARS-CoV-2 by narrowing down potential epitopes using HLA-DR transgenic mice and ELISpot assays.

The paper analyzes the genetic diversity and structural properties of SdrD in S. aureus PJI isolates, identifying three subtypes and showing structural rigidity despite calcium depletion.

This study identifies the structural basis for the dual function of SrtC2 in pilus assembly by showing how its extended lid modulates polymerization and anchoring activities.

The paper describes a new system for serial crystallography data collection using a 3D printed mesh-holder and high-performance computing pipeline, applied to two beta-lactamases.

This study identifies how SARS-CoV-2 PLpro selectively binds human ISG15 and K48-linked di-ubiquitin through dual domain recognition, revealing potential drug targets.

The paper determines the crystal structures of SARS-CoV-2 Nsp10/16 complexes before and after methylation, revealing the mechanism of RNA capping and its role in viral evasion of host defenses.

The paper shows that Tipiracil inhibits SARS-CoV-2 Nsp15 by binding to its uridine site, supporting its potential as a drug scaffold for antiviral development.

This paper reports structural and biochemical studies of SARS-CoV-2 papain-like protease and its complexes with inhibitors, showing their ability to inhibit enzyme activity and viral replication.

The paper identifies therapeutic genetic variations in Hsp104 homologs that specifically counter proteotoxicity in yeast, human cells, and C. elegans by enhancing passive chaperone activity.

The paper determines crystal structures of SARS-CoV-2 ADRP and shows conformational changes upon ligand binding, identifying a conserved water molecule involved in hydrolysis.

The paper reports the high-resolution crystal structure of SARS-CoV-2 Nsp15/NendoU and compares it with structures from SARS and MERS coronaviruses.

The paper determines the crystal structure of the SARS-CoV-2 nsp10-nsp16 heterodimer complex with S-adenosylmethionine at 1.80 Å resolution, revealing its role in viral mRNA capping and immune evasion.

The paper reports the 2.08 Å resolution structure of HLB5, a novel cellulase from Parabacteroides johnsonii, which lacks structural homologues or conserved regions typical of carbohydrate-degrading enzymes.