Author

L. D'Andrea

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Ecology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Assay:cryo-EM· 2 Research Focus:protein structure prediction· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. C. Whisstock· 3 shared A. M. Ellisdon· 2 shared C. Bayly-Jones· 2 shared C. Huang· 2 shared C. J. Lupton· 2 shared H. Venugopal· 2 shared M. L. Halls· 2 shared R. B. Schittenhelm· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBiochemistry

J. C. Whisstock

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Author profile →

5 papers

Recent·Most cited

The neoepitope of the complement C5b-9 Membrane Attack Complex is formed by proximity of adjacent ancillary regions of C9

C. Bayly-Jones, B. H. T. Ho, C. Lau, E. W. W. Leung, L. D'Andrea, C. J. Lupton, S. M. Ekkel, H. Venugopal, J. C. Whisstock, T. E. Mollnes, B. A. Spicer, M. A. Dunstone

This study identifies the discontinuous quaternary neoepitope of the C9 protein in the complement C5b-9 complex using cryo-EM, revealing its formation through adjacent domains without major conformational changes.

bioRxiv · Jul 6, 2022 · PreprintBiochemistry

The cryo-EM structure of the neurofibromin dimer reveals the molecular basis for von Recklinghausen disease

C. J. Lupton, C. Bayly-Jones, L. D'Andrea, C. Huang, R. B. Schittenhelm, H. Venugopal, J. C. Whisstock, M. L. Halls, A. M. Ellisdon

This paper determines the cryo-EM structure of full-length NF1, revealing its autoinhibited conformation and providing insights into disease mechanisms and therapeutic strategies.

bioRxiv · Feb 18, 2021 · PreprintBiochemistry

All is fish that comes to the net: metabarcoding for rapid fisheries catch assessment

T. Russo, G. Maiello, L. Talarico, C. Baillie, G. Colosimo, L. D'Andrea, F. Di Maio, F. Fiorentino, S. Franceschini, G. Garofalo, D. Scannella, S. Cataudella, S. Mariani

This study uses DNA metabarcoding on fishing net slush to assess fish catch composition, showing it mirrors visual inspection and correlates read counts with species abundance.

bioRxiv · Jun 18, 2020Ecology

Structural analysis of the PTEN:P-Rex2 signalling node reveals how cancer-associated mutations coordinate to hyperactivate Rac1

L. D'Andrea, C. M. Lucato, E. A. Marquez, Y.-G. Chang, S. Civciristov, C. Huang, H. Elmlund, R. B. Schittenhelm, C. A. Mitchell, J. C. Whisstock, M. L. Halls, A. M. Ellisdon

The paper investigates the PTEN:P-Rex2 complex, identifying how cancer mutations disrupt its inhibitory function and hyperactivate Rac1 signaling.

bioRxiv · Apr 11, 2020Biochemistry

Synthetic biogenesis of chromoplasts from leaf chloroplasts

B. LLORENTE, S. TORRES-MONTILLA, L. MORELLI, I. FLOREZ-SARASA, M. EZQUERRO, L. D'ANDREA, E. MAJER, A. TRONCOSO, A. FERNIE, J. A. DAROS, M. RODRIGUEZ-CONCEPCION

This study shows that artificially increasing phytoene production in chloroplasts triggers chromoplast differentiation in leaves, requiring reduced photosynthesis and increased carotenoid synthesis.

bioRxiv · Oct 25, 2019Plant Biology