Author

L. D. Sylvain

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

J. T. Hampton· 2 shared P.-H. C. Chen· 2 shared S. Xu· 2 shared W. R. Liu· 2 shared C. A. Fierke· 1 shared C.-C. Cho· 1 shared D. D. Coleman· 1 shared G. K. Dubey· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

J. T. Hampton

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

An Amber-Encoding Helper Phage for More Efficient Phage Display of Noncanonical Amino Acids

J. T. Hampton, C.-C. Cho, Z. Z. Geng, D. D. Coleman, P.-H. C. Chen, G. K. Dubey, L. D. Sylvain, S. Xu, W. R. Liu

This paper introduces a novel helper phage, CMa13ile40, that improves the efficiency of phage display by enabling rapid enrichment of amber codon-containing phage clones and enhancing the production of noncanonical amino acid (ncAA)-containing phages.

Nucleic Acids Research · Jun 9, 2023Peer-reviewedBiochemistry

Phage-Assisted, Active Site-Directed Ligand Evolution of a Potent and Selective Histone Deacetylase 8 Inhibitor

J. S. Morse, Y. J. Sheng, J. T. Hampton, L. D. Sylvain, S. Das, Y. R. Alugubelli, P.-H. C. Chen, K. S. Yang, S. Xu, C. A. Fierke, W. R. Liu

This paper develops PADLE, a phage-assisted method to evolve potent HDAC8 inhibitors, identifying two highly selective and potent inhibitors with sub-nanomolar Ki values.

bioRxiv · Sep 14, 2022Biochemistry