Author

P.-H. C. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 4 Approach:deep learning· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

S. Xu· 5 shared W. R. Liu· 5 shared Z. Z. Geng· 3 shared C. A. Fierke· 2 shared C.-C. Cho· 2 shared G. K. Dubey· 2 shared J. T. Hampton· 2 shared K. S. Yang· 2 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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5 shared papersBiochemistry

S. Xu

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Author profile →

5 papers

Recent·Most cited

An Amber-Encoding Helper Phage for More Efficient Phage Display of Noncanonical Amino Acids

J. T. Hampton, C.-C. Cho, Z. Z. Geng, D. D. Coleman, P.-H. C. Chen, G. K. Dubey, L. D. Sylvain, S. Xu, W. R. Liu

This paper introduces a novel helper phage, CMa13ile40, that improves the efficiency of phage display by enabling rapid enrichment of amber codon-containing phage clones and enhancing the production of noncanonical amino acid (ncAA)-containing phages.

Nucleic Acids Research · Jun 9, 2023Peer-reviewedBiochemistry

A Systematic Survey of Reversibly Covalent Dipeptidyl Inhibitors of the SARS-CoV-2 Main Protease

Z. Z. Geng, S. Atla, N. Shaabani, V. R. Vulupara, K. S. Yang, Y. R. Alugubelli, K. Khatua, P.-H. C. Chen, J. Xiao, L. R. Blankenship, X. R. Ma, E. C. Vatansever, C.-C. Cho, Y. Ma, R. Allen, , W. R. Liu

This study systematically evaluates dipeptidyl inhibitors of SARS-CoV-2 main protease, identifying compounds with high antiviral potency and low cytotoxicity.

bioRxiv · Jan 17, 2023Biochemistry

Phage-Assisted, Active Site-Directed Ligand Evolution with a Genetically Encoded Nε-Butyryl-ʟ-Lysine to Identify a Cellularly Potent and Selective Inhibitor for the ENL YEATS Domain as an Anti-Leukemia Agent

P.-H. C. Chen, X. S. Guo, H. E. Zhang, Z. Z. Geng, G. K. Dubey, C. A. Fierke, S. Xu, W. R. Liu

This study develops a phage-assisted ligand evolution method to identify potent ENL inhibitors, finding a pentapeptide with sub-nanomolar affinity and anti-leukemia activity.

bioRxiv · Jan 8, 2023 · PreprintBiochemistry

The Prioritization of Eleven-Nineteen-Leukemia Inhibitors as Potential Drug Candidates to Treat Acute Myeloid Leukemia

X. S. Guo, P.-H. C. Chen, S. Xu, W. R. Liu

This study identifies compound 13 as a potent ENL inhibitor with favorable pharmacokinetic properties for treating AML with MLL-fusion mutations.

bioRxiv · Dec 7, 2022 · PreprintBiochemistry

Phage-Assisted, Active Site-Directed Ligand Evolution of a Potent and Selective Histone Deacetylase 8 Inhibitor

J. S. Morse, Y. J. Sheng, J. T. Hampton, L. D. Sylvain, S. Das, Y. R. Alugubelli, P.-H. C. Chen, K. S. Yang, S. Xu, C. A. Fierke, W. R. Liu

This paper develops PADLE, a phage-assisted method to evolve potent HDAC8 inhibitors, identifying two highly selective and potent inhibitors with sub-nanomolar Ki values.

bioRxiv · Sep 14, 2022Biochemistry