Author

L. D. Troughton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Approach:experimental assay· 6 Organism:human· 4 Assay:imaging· 4 Research Focus:cell signaling & trafficking· 3 Assay:proteomics· 3 Research Focus:cell-cell communication· 2 Organism:mouse· 2

Frequent Co-Authors

K. J. Hamill· 4 shared C. J. Sugden· 3 shared P. W. Oakes· 3 shared V. Iorio· 2 shared A. Chatterjee· 1 shared A. Cody· 1 shared B. A. Cisterna Irrazabal· 1 shared b. stramer· 1 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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4 shared papersCell Biology

K. J. Hamill

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Non-muscle myosin 2 filaments are processive in cells

E. A. Vitriol, M. A. Quintanilla, J. J. Tidei, L. D. Troughton, A. Cody, B. A. Cisterna Irrazabal, M. L. Jane, P. W. Oakes, J. R. Beach

This study shows non-muscle myosin 2 (NM2) filaments are processive in cells, moving against actin flow in protrusions and stress fibers, with NM2A slightly faster than NM2B.

bioRxiv · Feb 24, 2023Cell Biology

Atypical peripheral actin band formation via overactivation of RhoA and Non-muscle myosin II in Mitofusin 2 deficient cells

Y. Wang, L. D. Troughton, F. Xu, A. Chatterjee, H. Zhao, L. P. Cifuentes, R. B. Wagner, J. Chen, S. Kuang, D. M. Suter, C. Yuan, D. Chan, F. Huang, P. W. Oakes, Q. Deng

This study shows that MFN2 deficiency leads to increased cytosolic Ca2+ and overactivation of RhoA and non-muscle myosin II, causing atypical peripheral actin band formation in mouse embryonic fibroblasts.

bioRxiv · Oct 3, 2022Cell Biology

A Workflow for Rapid Unbiased Quantification of Fibrillar Feature Alignment in Biological Images

S. Marcotti, D. B. de Freitas, L. D. Troughton, F. N. Kenny, T. J. Shaw, b. stramer, P. W. Oakes

This paper introduces AFT, a workflow using 2D FFT to quantify fibrillar feature alignment in microscopy images, showing advantages in flexibility, parameter efficiency, and computational speed.

Frontiers in Computer Science · Oct 14, 2021Peer-reviewedBiophysics

Laminin N-terminus α31 regulates keratinocyte adhesion and migration through modifying the organisation and proteolytic processing of laminin 332.

L. D. Troughton, V. Iorio, L. Shaw, C. J. Sugden, K. Yamamoto, K. J. Hamill

This study shows LaNt 31 regulates keratinocyte adhesion and migration by altering laminin 332 organization and proteolytic processing.

bioRxiv · Jul 28, 2020 · PreprintCell Biology

Laminin N-terminus α31 expression during development is lethal and causes widespread tissue-specific defects in a transgenic mouse model.

C. J. Sugden, V. Iorio, L. D. Troughton, K. Liu, G. Bou-Gharios, K. J. Hamill

This study shows that expressing LaNt 31 during mouse development causes tissue-specific defects and basement membrane disruption, supporting a model of laminin self-regulation.

bioRxiv · Jul 26, 2020Cell Biology

Laminin N-terminus α31 is upregulated in invasive ductal breast cancer and changes the mode of tumour invasion.

L. D. Troughton, T. Zech, K. J. Hamill

This study shows LaNt 31 is upregulated in invasive ductal breast cancer and alters the mode of tumor invasion from multicellular streaming to individual cell invasion.

bioRxiv · May 28, 2020Cancer Biology

Laminin N-terminus α31 protein distribution in adult human tissues

L. D. Troughton, R. Reuten, C. J. Sugden, K. J. Hamill

This study uses immunohistochemistry to map LaNt 31 expression across human tissues, revealing widespread distribution in epithelial, vascular, and neuronal contexts.

bioRxiv · May 21, 2020Cell Biology