Author

J. R. Beach

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 5 Approach:experimental assay· 5 Research Focus:cell type annotation· 2 Assay:fluorescence / live-cell microscopy· 2 Organism:human· 2 Approach:microscopy & imaging analysis· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

M. A. Quintanilla· 3 shared P. W. Oakes· 3 shared H. Patel· 2 shared H. Wu· 2 shared A. Cody· 1 shared A. J. Nelson· 1 shared B. A. Cisterna Irrazabal· 1 shared B. Somerfield· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersCell Biology

M. A. Quintanilla

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Lung-resident memory B cells maintain allergic IgE responses in the respiratory tract

A. J. Nelson, T. K. Bruna, J. R. Beach, D. K. Sojka, Y. L. Wu

This study identifies lung-resident memory B cells as a key source of allergen-specific IgE in the respiratory tract and shows their role in maintaining allergic asthma.

Immunity · Apr 1, 2025Peer-reviewedImmunology

The PCM scaffold enables RNA localization to centrosomes

J. Fang, W. Tian, M. A. Quintanilla, J. R. Beach, D. A. Lerit

The paper investigates how Plp mRNA localizes to centrosomes, showing that its coding sequence is necessary and sufficient for localization and that PCM scaffold interactions facilitate this process.

bioRxiv · Jan 13, 2024Cell Biology

Local Monomer Levels and Established Filaments Potentiate Non-Muscle Myosin 2 Assembly

M. A. Quintanilla, H. Patel, H. Wu, K. A. Sochacki, M. Akamatsu, J. D. Rotty, F. Korobova, J. E. Bear, J. W. Taraska, P. W. Oakes, J. R. Beach

This study identifies biophysical mechanisms regulating non-muscle myosin 2 filament assembly using dynamic imaging and optogenetic tools, showing myosin monomer concentration and myosin:myosin interactions drive filament formation.

bioRxiv · Apr 26, 2023Cell Biology

Non-muscle myosin 2 filaments are processive in cells

E. A. Vitriol, M. A. Quintanilla, J. J. Tidei, L. D. Troughton, A. Cody, B. A. Cisterna Irrazabal, M. L. Jane, P. W. Oakes, J. R. Beach

This study shows non-muscle myosin 2 (NM2) filaments are processive in cells, moving against actin flow in protrusions and stress fibers, with NM2A slightly faster than NM2B.

bioRxiv · Feb 24, 2023Cell Biology

Vascular Smooth Muscle Myosin 2 Filaments Dynamically Assemble and Stabilize During Induced Contractility

S. G. Demeulenaere, M. A. Bennett, B. Somerfield, H. Wu, U. E. Margaret, H. Patel, S. Sala, E. R. Longtine, Z. Ahmed, J. A. Kirk, P. W. Oakes, J. R. Beach

This study investigates SMII filament dynamics in vascular smooth muscle cells, showing they are dynamic and stabilize during contraction, with implications for vascular regulation and disease.

bioRxiv · Oct 10, 2022Cell Biology

Inhibitory and Stimulatory Micropeptides Preferentially Bind to Different Conformations of the Cardiac Calcium Pump

S. R. Cleary, X. Fang, E. E. Cho, M. P. Pribadi, J. Seflova, J. R. Beach, P. Kekenes-Huskey, S. L. Robia

The paper shows that inhibitory and stimulatory micropeptides bind to different conformations of the cardiac calcium pump SERCA, with their binding preference depending on intracellular Ca2+ levels.

bioRxiv · Jun 15, 2021Biophysics