Author

I. Jungreis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cancer Biology· 1 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Organism:human· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

M. Kellis· 3 shared A. Apffel· 1 shared A. Boppana· 1 shared A. D. Davidson· 1 shared A. E. Firth· 1 shared A. Gladfelter· 1 shared A. M. Whited· 1 shared A. Regev· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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3 shared papersBiophysics

M. Kellis

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Biophysical characterization of high-confidence, small human proteins

A. M. Whited, I. Jungreis, J. Allen, C. Cleveland, J. M. Mudge, M. Kellis, J. Rinn, L. E. Hough

The paper characterizes biophysical properties of small human proteins, finding significant differences compared to larger proteins and providing insights for distinguishing functional from non-coding small open reading frames.

bioRxiv · Apr 12, 2024Biophysics

The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity

H. Stewart, Y. Lu, S. O'Keefe, A. Valpadashi, L. D. Cruz-Zaragoza, H. A. Michel, S. K. Nguyen, G. W. Carnell, N. Lukhovitskaya, R. Milligan, I. Jungreis, V. Lulla, A. D. Davidson, D. A. Matthews, S. High, , A. E. Firth

This study identifies ORF3c as a SARS-CoV-2 protein that localizes to mitochondria and inhibits IFN-β production without affecting NF-κB or JAK-STAT signaling.

bioRxiv · Nov 15, 2022Microbiology

Specific viral RNA drives the SARS CoV-2 nucleocapsid to phase separate

C. Iserman, C. A. Roden, M. Boerneke, R. Sealfon, G. McLaughlin, I. Jungreis, C. Y. Park, A. Boppana, E. Fritch, Y. Hou, C. Theesfeld, O. Troyanskaya, R. S. G. Baric, T. P. Sheahan, K. Weeks, A. Gladfelter

This study shows SARS-CoV-2 N-protein forms liquid-liquid phase separation with specific viral RNA sequences, which is temperature-sensitive and can be modulated by small molecules, offering potential for antiviral drug development.

bioRxiv · Jun 11, 2020 · PreprintBiochemistry

Thousands of novel unannotated proteins expand the MHC I immunopeptidome in cancer

T. Ouspenskaia, T. Law, K. R. Clauser, S. Klaeger, S. Sarkizova, F. Aguet, B. Li, E. Christian, B. A. Knisbacher, P. M. Le, C. R. Hartigan, H. Keshishian, A. Apffel, G. Oliveira, W. Zhang, , A. Regev

The paper identifies thousands of novel unannotated proteins in cancer that contribute to the MHC I immunopeptidome, expanding potential targets for immunotherapy.

bioRxiv · Feb 12, 2020 · PreprintCancer Biology

Elucidation of Codon Usage Signatures across the Domains of Life

E. M. Novoa, O. Jaillon, I. Jungreis, M. Kellis

The paper identifies arginine as a major contributor to codon usage bias across domains of life and shows that domain-specific codon bias signatures can classify sequences into their domain with high accuracy.

bioRxiv · Sep 26, 2018Evolutionary Biology