Author

N. C. Fitzkee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 6 Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 6 Approach:experimental assay· 4 Approach:statistical model· 4 Assay:protein sequence· 3 Assay:proteomics· 3 Research Focus:benchmarking· 2 Approach:deep learning· 2 Organism:human· 2

Frequent Co-Authors

C. S. Kariyawasam· 3 shared D. L. Amarasekara· 3 shared L. E. Hough· 3 shared S. T. Whitten· 3 shared J. J. Correia· 2 shared K. A. Lewis· 2 shared R. P. Somarathne· 2 shared R. Yadav· 2 shared

Activity by Year

2021-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersBiophysics

C. S. Kariyawasam

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Exploring the Residue-Level Interactions between the R2ab Protein and Polystyrene Nanoparticles

R. P. Somarathne, S. K. Misra, C. S. Kariyawasam, J. J. Kessl, J. S. Sharp, N. C. Fitzkee

This paper investigates residue-level interactions between the R2ab protein and polystyrene nanoparticles using mass spectrometry and HDX NMR, revealing conformational changes and supporting the adsorbotope model.

bioRxiv · Aug 28, 2023 · PreprintBiophysics

Near-Infrared Photothermal Ablation of Biofilms using Protein-Functionalized Gold Nanospheres with a Tunable Temperature Response

D. L. Amarasekara, C. S. Kariyawasam, M. A. Hejny, V. B. Torgall, T. A. Werfel, N. C. Fitzkee

This paper develops temperature-responsive gold nanospheres for photothermal ablation of biofilms, showing enhanced antimicrobial efficacy at tunable transition temperatures.

bioRxiv · Aug 12, 2023 · PreprintBioengineering

Protein Binding Leads to Reduced Stability and Solvated Disorder in the Polystyrene Nanoparticle Corona

R. P. Somarathne, D. L. Amarasekara, C. S. Kariyawasam, H. A. Robertson, R. Mayatt, N. C. Fitzkee

The paper models protein corona disorder on polystyrene nanoparticles, finding that larger nanoparticles lead to less protein destabilization and more solvated, disordered coronas.

bioRxiv · Jul 6, 2023Biophysics

ParSe 2.0: A web application that enables proteome-scale searches for sequences that drive protein-mediated phase separation

C. Wilson, K. A. Lewis, N. C. Fitzkee, L. E. Hough, S. T. Whitten

ParSe 2.0 predicts protein regions that drive phase separation using sequence-based descriptors and is available as a web application.

bioRxiv · Jun 20, 2023Biophysics

Mechanistic basis of staphylococcal interspecies competition for skin colonization

J. J. Maciag, C. Chantraine, K. B. Mills, R. Yadav, A. E. Yarawsky, C. T. Chaton, D. Vinod, N. C. Fitzkee, M. Mathelie-Guinlet, Y. F. Dufrene, P. D. Fey, A. R. Horswill, A. B. Herr

This study investigates the structural and functional basis of staphylococcal adhesion to skin and reveals cross-inhibition between S. epidermidis and S. aureus.

bioRxiv · Jan 26, 2023 · PreprintMicrobiology

Intrinsically disordered regions that drive phase separation form a robustly distinct protein class

A. Y. Ibrahim, N. P. Khaodeuanepheng, D. L. Amarasekara, J. J. Correia, K. A. Lewis, N. C. Fitzkee, L. E. Hough, S. T. Whitten

The paper identifies amino acid property scales that distinguish phase-separating intrinsically disordered regions from other protein regions and improves a predictor for these regions.

bioRxiv · Aug 4, 2022Biophysics

Predicting Protein Function and Orientation on a Gold Nanoparticle Surface Using a Residue-Based Affinity Scale

J. X. Xu, M. S. Alom, R. Yadav, N. C. Fitzkee

This paper develops a residue-based affinity scale to predict protein orientation on gold nanoparticles, showing it accurately predicts orientation and activity for several enzymes.

bioRxiv · Mar 29, 2022 · PreprintBiophysics

Beta Turn Propensity and a Model Polymer Scaling Exponent Identify Disordered Proteins that Phase Separate

E. A. Paiz, J. H. Allen, J. J. Correia, N. C. Fitzkee, L. E. Hough, S. T. Whitten

The paper identifies disordered proteins that phase separate by analyzing their polymer scaling exponent and beta-turn propensity, introducing a new algorithm, ParSe.

Journal of Biological Chemistry · Nov 1, 2021Peer-reviewedBiophysics