Identification and characterization of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates
E. K. O'Shea, Z. Yu, L. E. Surface, C. Y. Park, M. A. Horlbeck, G. A. Wyant, M. Abu-Remaileh, T. R. Peterson, D. M. Sabatini, J. S. Weissman
The paper identifies SLC37A3 as a transporter required for nitrogen-containing bisphosphonates (N-BPs) to enter the cytosol, revealing their mechanism of action.
bioRxiv · Mar 27, 2018Biochemistry