Author

M. A. Horlbeck

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Approach:genetic perturbation / CRISPR· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

J. S. Weissman· 5 shared M. Jost· 3 shared M. E. Tanenbaum· 2 shared M. Kampmann· 2 shared A. Akhmanova· 1 shared A. E. Prota· 1 shared A. Rai· 1 shared B. S. Phinney· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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5 shared papersCell Biology

J. S. Weissman

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Author profile →

5 papers

Recent·Most cited

CRISPRi screens identify the lncRNA, LOUP, as a multifunctional locus regulating macrophage differentiation epigenetically and inflammatory signaling through a short, encoded peptide

H. Halasz, E. Malekos, S. Covarrubias, S. Yitiz, C. Montano, L. Sudek, S. Katzman, S. J. Liu, M. A. Horlbeck, J. S. Weissman, S. Carpenter

The paper uses CRISPRi screens to identify the lncRNA LOUP as a regulator of macrophage differentiation and inflammatory signaling through epigenetic and peptide-mediated mechanisms.

bioRxiv · Dec 19, 2023 · PreprintImmunology

Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells

M. Le Vasseur, J. R. Friedman, M. Jost, J. Xu, J. Yamada, M. Kampmann, M. A. Horlbeck, M. R. Salemi, B. S. Phinney, J. S. Weissman, J. Nunnari

bioRxiv · Feb 16, 2021Cell Biology

High-content Imaging-based Pooled CRISPR Screens in Mammalian Cells

X. Yan, N. Stuurman, S. A. Ribeiro, M. E. Tanenbaum, M. A. Horlbeck, C. R. Liem, M. Jost, J. S. Weissman, R. Vale

The paper develops an imaging-based CRISPR screening method called optical enrichment to identify genes affecting nuclear size, identifying 14 hits from 6092 sgRNAs.

bioRxiv · Jun 30, 2020Cell Biology

Pharmaceutical-grade Rigosertib is a Microtubule-destabilizing Agent

M. Jost, Y. Chen, L. A. Gilbert, M. A. Horlbeck, L. Krenning, G. Menchon, A. Rai, M. Y. Cho, J. J. Stern, A. E. Prota, M. Kampmann, A. Akhmanova, M. O. Steinmetz, M. E. Tanenbaum, J. S. Weissman

This paper shows pharmaceutical-grade rigosertib, with high purity, causes microtubule destabilization in cells, confirming its mechanism of action against cancer cells.

bioRxiv · Jan 28, 2020Cancer Biology

Identification and characterization of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates

E. K. O'Shea, Z. Yu, L. E. Surface, C. Y. Park, M. A. Horlbeck, G. A. Wyant, M. Abu-Remaileh, T. R. Peterson, D. M. Sabatini, J. S. Weissman

The paper identifies SLC37A3 as a transporter required for nitrogen-containing bisphosphonates (N-BPs) to enter the cytosol, revealing their mechanism of action.

bioRxiv · Mar 27, 2018Biochemistry