H. Maiato

The deubiquitylase USP31 controls the Chromosomal Passenger Complex and spindle dynamics

This study identifies USP31 as a deubiquitylase regulating the chromosomal passenger complex and spindle dynamics during mitosis, leading to chromosomal segregation errors and polyploidy upon depletion.

Long-term mitotic DNA damage promotes chromokinesin-mediated missegregation of polar chromosomes in cancer cells

The paper shows that long-term mitotic DNA damage in cancer cells leads to chromokinesin-mediated missegregation of polar chromosomes via stabilized kinetochore-microtubule attachments.

Misaligned chromosomes that satisfy the spindle assembly checkpoint are a strong predictor of micronuclei formation in dividing cancer cells

The paper shows that chronically misaligned chromosomes satisfying the SAC predict micronuclei formation in cancer cells but not in normal cells.

CLASP2 stabilizes GDP-associated terminal tubulins to prevent microtubule catastrophe

This study identifies CLASP2's mechanism of stabilizing GDP-associated terminal tubulins to prevent microtubule catastrophe.

Mechanosensitive control of mitotic entry

The paper identifies a mechanical signal on the nucleus that regulates mitotic entry by activating cyclin B1 translocation through actomyosin contractility and cPLA2.

Kinetochore-mediated microtubule assembly and Augmin-dependent amplification drive k-fiber maturation in mammals

The paper investigates k-fiber maturation in mammals, revealing that Augmin promotes microtubule formation and amplification from kinetochores, essential for spindle assembly.

An anaphase surveillance mechanism prevents micronuclei formation from mitotic errors

This study identifies an Aurora B kinase-mediated mechanism that prevents micronuclei formation by integrating error correction with nuclear envelope reformation during anaphase.

Microtubule poleward flux in human cells is driven by the coordinated action of four kinesins

This study identifies four kinesins that coordinate to drive microtubule poleward flux in human cells, which is essential for regulating spindle size during mitosis.

Mechanosensitive nuclear asymmetries define a bipolar spindle scaffold to ensure mitotic fidelity

The paper shows that nuclear asymmetry during prophase, driven by mechanical cues, enables proper centrosome positioning and bipolar spindle formation for accurate mitosis.

Microtubule tyrosination/detyrosination specifies a mitotic error code

The paper shows that microtubule tyrosination/detyrosination regulates mitotic error correction by modulating MCAK activity, acting as a mitotic error code.

CLASP2 lattice-binding near microtubule plus ends stabilizes kinetochore attachments

This study identifies CLASP2's role in stabilizing kinetochore microtubule attachments through lattice-binding near microtubule plus ends, ensuring accurate chromosome segregation.

Mitotic exit is controlled during anaphase by an Aurora B-Cyclin B1/Cdk1 crosstalk

The paper shows that Cyclin B1 degradation during anaphase, regulated by Aurora B and kinesin-6, is essential for mitotic exit, reconciling the 'clock' and 'ruler' models.

Coherent-hybrid STED: a tunable photo-physical pinhole for super-resolution imaging at high contrast

This paper introduces CH-STED, a super-resolution imaging technique that improves optical sectioning and reduces background fluorescence for high-contrast imaging of biological structures.

Mitotic progression, arrest, exit or death is determined by centromere integrity and independent of de novo transcription

This study investigates the role of de novo transcription during mitosis and finds that centromere integrity, not transcription, determines mitotic progression, arrest, exit, or death.

Chromosome (mis)segregation is biased by kinetochore size

The paper investigates how kinetochore size affects chromosome segregation in human cells using the Indian muntjac, revealing that larger kinetochores lead to biased segregation outcomes.