L. I. Jones

O-GlcNAc transferase regulates H2O2 production via p38 MAPK

This paper shows that OGT inhibition reduces TGF-β-induced p38 MAPK signaling and H2O2 production in lung fibroblasts through O-GlcNAcylation of p38 and p47phox.

CD248 activates TGF-β receptor I to promote vascular remodeling in pulmonary arterial hypertension

This study identifies CD248 as a co-activator of TGF-β receptor I in pulmonary arterial hypertension, supporting anti-CD248 therapy as a targeted alternative to systemic TGF-β inhibition.

Pulmonary Fibrosis Ferret Model Demonstrates Sustained Fibrosis, Restrictive Physiology, and Aberrant Repair

This study shows that bleomycin-exposed ferrets develop sustained pulmonary fibrosis, restrictive lung physiology, and airway remodeling similar to human IPF.