Author

L. Kruglyak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Evolutionary Biology· 4 Genetics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:C. elegans· 3 Research Focus:chromatin & epigenetic regulation· 3 Assay:DNA methylation· 3 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Assay:whole-genome sequencing· 3 Organism:yeast· 2

Frequent Co-Authors

J. S. Bloom· 3 shared S. Zdraljevic· 2 shared A. Burga· 1 shared B. Seo· 1 shared C. Braendle· 1 shared D. H. W. Leighton· 1 shared D.C. Cook· 1 shared D.D. Riccardi· 1 shared

Activity by Year

2016-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersEvolutionary Biology

J. S. Bloom

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Divergent C. elegans toxin alleles are suppressed by distinct mechanisms

S. Zdraljevic, L. Walter-McNeill, G. Bruni, H. Marquez, J. Collins, D. H. W. Leighton, N. Alexander, J. S. Bloom, L. Kruglyak

The paper identifies a new TA system in C. elegans with divergent toxin alleles suppressed by distinct mechanisms, including piRNA-mediated silencing in the N2 haplotype.

bioRxiv · Apr 26, 2024Evolutionary Biology

Towards Synthetic PETtrophy: Engineering Pseudomonas putida for concurrent polyethylene terephthalate (PET) monomer metabolism and PET hydrolase expression

O. F. Brandenberg, O. T. Schubert, L. Kruglyak

This paper engineers Pseudomonas putida to metabolize PET monomers and express PET hydrolases, finding that extracellular enzyme expression can be achieved but often reduces host fitness.

bioRxiv · Apr 21, 2022Microbiology

Ancient balancing selection maintains incompatible versions of a conserved metabolic pathway in yeast

J. Boocock, M. J. Sadhu, J. S. Bloom, L. Kruglyak

The paper identifies ancient balancing selection maintaining incompatible galactose metabolic pathway variants in yeast, revealing a tradeoff between growth in galactose and glucose.

bioRxiv · Nov 4, 2019Evolutionary Biology

A maternal-effect genetic incompatibility in Caenorhabditis elegans

E. Ben-David, A. Burga, L. Kruglyak

The paper identifies a maternal-effect genetic incompatibility in C. elegans caused by a selfish element composed of sup-35 and pha-1.

Science · Jun 9, 2017Peer-reviewedEvolutionary Biology

Genetic Variation In Adaptability And Pleiotropy In Budding Yeast

E. R. Jerison, S. Kryazhimskiy, J. Mitchell, J. S. Bloom, L. Kruglyak, M. M. Desai

The paper quantifies genetic variation in adaptability and pleiotropy in budding yeast offspring, finding that initial genotype affects adaptability and pleiotropy, with heritable differences arising from natural variation.

bioRxiv · Mar 29, 2017Evolutionary Biology

The genetic basis of natural variation in C. elegans telomere length

D.C. Cook, S. Zdraljevic, R.E. Tanny, B. Seo, D.D. Riccardi, L.M. Noble, M.V. Rockman, M.J. Alkema, C. Braendle, J.E. Kammenga, J. Wang, L. Kruglyak, M.A. Félix, J. Lee, E.C. Andersen

This study identifies a genetic variant affecting telomere length in C. elegans and finds no correlation between telomere length and fitness traits.

bioRxiv · May 2, 2016 · PreprintGenetics