Author

L. M. Hürlimann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Assay:ATAC-seq· 1 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1

Frequent Co-Authors

C. A. J. Hutter· 3 shared M. A. Seeger· 3 shared G. Meier· 2 shared I. Zimmermann· 2 shared P. Egloff· 2 shared S. Thavarasah· 2 shared E. Bordignon· 1 shared H. Göddeke· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersBiochemistry

C. A. J. Hutter

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3 papers

Recent·Most cited

BiochemistrybioRxivOct 1, 2021

Deep mutational scan of a drug efflux pump reveals its structure-function landscape

G. Meier, S. Thavarasah, K. Ehrenbolger…·M. A. Seeger

The paper uses deep mutational scanning to analyze the structure-function relationship of the EfrCD drug efflux pump, revealing how mutations affect drug efflux and identifying mutations that convert it into a drug importer.

DOI 10.1038/s41589-022-01205-1

bacteria (other)ATAC-seq

𝕏 PostBluesky

BiochemistrybioRxivPreprintApr 16, 2020

Sybodies targeting the SARS-CoV-2 receptor-binding domain

J. D. Walter, C. A. J. Hutter, I. Zimmermann…·M. A. Seeger

This paper reports the rapid in vitro selection of sybodies targeting the SARS-CoV-2 receptor-binding domain, identifying potent inhibitors with ACE2 blocking activity and potential for therapeutic development.

DOI 10.1101/2020.04.16.045419

experimental assaydrug response / drug discovery

𝕏 PostBluesky

BiochemistrybioRxivSep 18, 2018

The extracellular gate shapes the energy profile of an ABC exporter

C. A. J. Hutter, M. H. Timachi, L. M. Hürlimann…·M. A. Seeger

This study uses a synthetic antibody to determine the structure and mechanism of an ABC exporter's extracellular gate, showing its role in ATPase activity and transport.

DOI 10.1038/s41467-019-09892-6

structural biologyexperimental assay

𝕏 PostBluesky