C. A. J. Hutter

Deep mutational scan of a drug efflux pump reveals its structure-function landscape

The paper uses deep mutational scanning to analyze the structure-function relationship of the EfrCD drug efflux pump, revealing how mutations affect drug efflux and identifying mutations that convert it into a drug importer.

Mechanistic basis of choline import involved in teichoic acids and lipopolysaccharide modification

This study characterizes the structure and function of LicB, a choline transporter in Streptococcus pneumoniae, revealing its proton-coupled import mechanism and potential as a target for inhibition.

Biparatopic sybody constructs neutralize SARS-CoV-2 variants of concern and mitigate emergence of drug resistance

A potent synthetic nanobody targets RBD and protects mice from SARS-CoV-2 infection

Sybodies targeting the SARS-CoV-2 receptor-binding domain

This paper reports the rapid in vitro selection of sybodies targeting the SARS-CoV-2 receptor-binding domain, identifying potent inhibitors with ACE2 blocking activity and potential for therapeutic development.

The extracellular gate shapes the energy profile of an ABC exporter

This study uses a synthetic antibody to determine the structure and mechanism of an ABC exporter's extracellular gate, showing its role in ATPase activity and transport.