Author

L. Machesky

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Research Focus:development & morphogenesis· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

A. Farima· 1 shared A. H. Le· 1 shared A. Moye· 1 shared A. Turpin· 1 shared A. von Kriegsheim· 1 shared B. Goode· 1 shared C. Bruschini· 1 shared D. Faccio· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperBioengineering

A. Farima

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Ciliary tip actin dynamics regulate the cadenceof photoreceptor disc formation

R. Megaw, A. Moye, Z. Zhang, F. Newton, F. McPhie, L. C. Murphy, L. McKie, F. He, M. K. Jungnickel, A. von Kriegsheim, L. Machesky, T. G. Wensel, P. Mill

This study shows that actin dynamics at photoreceptor cilia tips regulate disc formation, and RPGR mutations disrupt this process, leading to retinal degeneration.

bioRxiv · Nov 10, 2022Cell Biology

CYRI-A regulates macropinocytic cup maturation and mediates integrin uptake, limiting invasive migration

A. H. Le, T. Yelland, N. Paul, L. Fort, S. Nikolaou, S. Ismail, L. Machesky

This study identifies CYRI-A as a regulator of macropinocytic cup maturation and integrin uptake, showing its role in limiting invasive migration.

bioRxiv · Dec 4, 2020Cell Biology

Wide-field Fluorescence Lifetime Imaging Microscopy with a High-Speed Mega-pixel SPAD Camera

V. Zickus, M. L. Wu, K. Morimoto, V. Kapitany, A. Farima, A. Turpin, R. Insall, J. Whitelaw, L. Machesky, C. Bruschini, D. Faccio, E. Charbon

This paper introduces a high-speed wide-field FLIM system using a SPAD camera and neural network for faster lifetime estimation, demonstrating real-time imaging capabilities.

bioRxiv · Jun 7, 2020 · PreprintBioengineering

Cell-substrate adhesion drives Scar/WAVE activation and phosphorylation, which controls pseudopod lifetime

S. Singh, P. Thomason, S. Lilla, M. Schacks, Q. Tang, B. Goode, L. Machesky, K. Rottner, R. H. Insall

The paper shows that cell-substrate adhesion drives Scar/WAVE phosphorylation, which limits pseudopod lifetime, independent of chemotactic signals.

bioRxiv · Aug 12, 2019 · PreprintCell Biology