A. von Kriegsheim

SCD inhibition eradicates AML displaying high de novo fatty acid desaturation and synergizes with chemotherapy

SCD inhibition induces AML cell death and synergizes with chemotherapy to prolong survival in murine AML models.

Comparative proximity biotinylation implicates RAB18 in sterol mobilization and biosynthesis

This study uses proximity biotinylation to identify RAB18 interactors, revealing its role in sterol mobilization and biosynthesis, with implications for Warburg Micro syndrome.

Ciliary tip actin dynamics regulate the cadenceof photoreceptor disc formation

This study shows that actin dynamics at photoreceptor cilia tips regulate disc formation, and RPGR mutations disrupt this process, leading to retinal degeneration.

Quantitative proteomics identifies tumour matrisome signatures in patients with non-small cell lung cancer

The paper identifies tumour-specific ECM proteome signatures in NSCLC patients using mass spectrometry, finding 161 differentially regulated matrisome proteins and two novel extracellular markers associated with poorer survival.

Strongly truncated Dnaaf4 plays a conserved role in Drosophila ciliary dynein assembly as part of an R2TP-like co-chaperone complex with Dnaaf6

This study shows that Drosophila Dnaaf4 and Dnaaf6 form an R2TP-like complex essential for dynein assembly in ciliated cells, despite Dnaaf4 lacking a TPR domain.

Nitrogen partitioning between branched-chain amino acids and urea cycle enzymes sustains renal cancer progression

This study identifies metabolic reprogramming in renal cancer cells, showing how branched-chain amino acid catabolism and urea cycle enzymes support tumor progression and metastasis.

Characterisation of a nucleo-adhesome

The paper identifies a nucleo-adhesome, showing that adhesion proteins localize to the nucleus and regulate transcription through interactions like FAK and Hic-5.

Mena regulates the LINC complex to control actin-nuclear lamina associations, trans-nuclear membrane signalling and cancer gene expression

This study identifies Mena's role in regulating the LINC complex and nuclear architecture, linking it to cancer gene expression through nuclear membrane signaling.

Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism

This study investigates the effects of TCA cycle inhibition on redox and amino acid metabolism, revealing ATF4-dependent metabolic rewiring and distinct responses between FH and SDH inhibition.

The Drosophila orthologue of the primary ciliary dyskinesia-associated gene, DNAAF3, is required for axonemal dynein assembly

This study identifies Dnaaf3 as essential for axonemal dynein assembly in Drosophila, leading to defects in mechanosensory and reproductive functions.

RASSF1C oncogene elicits amoeboid invasion, cancer stemness and invasive EVs via a novel SRC/Rho axis

This study shows RASSF1C promotes amoeboid invasion, cancer stemness, and invasive extracellular vesicles through SRC/Rho axis activation in breast cancer.

A novel role of MNT as a negative regulator of REL and the NF-κB pathway

This study identifies MNT as a negative regulator of the NF-κB pathway by inhibiting REL translocation and repressing REL-target genes through a MNT-REL complex.

Asparagine hydroxylation is likely to be a reversible post-translational modification

The paper shows that asparagine hydroxylation can be reversed by cellular machinery, challenging the view that it is irreversible.

ISGylation drives basal breast tumour progression by promoting EGFR recycling and Akt signalling

This study shows that ISGylation promotes breast tumour progression by enhancing EGFR recycling and Akt signalling, acting as a driver rather than just a marker of cancer.

A Synergistic Anti-Cancer FAK and HDAC Inhibitor Combination Discovered by a Novel Chemical-Genetic High Content Phenotypic Screen

The paper identifies a synergistic combination of FAK and HDAC inhibitors using a chemical-genetic high-content screen, showing efficacy in cancer cell lines and in vivo.

iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE

This study identifies iTAP as a novel iRhom interactor that stabilizes iRhom and TACE, essential for TNF secretion, and shows its role in regulating inflammation.

An efficient and scalable pipeline for epitope tagging in mammalian stem cells using Cas9 ribonucleoprotein

The paper introduces an efficient, selection-free, and scalable CRISPR/Cas9-based pipeline for epitope tagging in mammalian stem cells, achieving knock-in efficiencies of 5-30%.

ZMYND10 functions in a chaperone relay during axonemal dynein assembly

This study identifies ZMYND10 as a co-chaperone for FKBP8-HSP90 in axonemal dynein assembly, showing its role in ciliary motility and implications for PCD treatment.