Impairing flow-mediated endothelial remodeling reduces extravasation of tumor cells
G. FOLLAIN, N. OSMANI, L. MERCIER, M. J. GARCIA-LEON, I. BUSNELLI, A. PICHOT, N. PAUL, R. CARAPITO, S. BAHRAM, O. LEFEBVRE, J. G. GOETZ
This study shows that blood flow promotes VEGFR signaling in endothelial cells, driving remodeling that facilitates tumor cell extravasation, and that inhibiting VEGFR reduces this process.
bioRxiv · Jul 27, 2020Cancer Biology